Methods for treating viral conditions

A method for inhibiting or reducing viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects, comprising contacting an effective amount of a compound having Formula (I) with a cell or a cell line that produces viral RNA or DNA, viral protein or a virus induced cytopathic effect or is induced to produce viral RNA or DNA, viral protein or a virus induced cytopathic effects:

• or a pharmaceutically acceptable salt, racemate, tautomer or stereoisomer thereof, wherein,
• W is hydrogen;
• or halogen;
• X is hydrogen;
• optionally substituted C1 to C8 alkyl;
• hydroxyl;
• halogen;
• thioether;
• sulfinyl;
• sulfonyl;
• cyano;
• or optionally substituted C1 to C8;
• Y is hydrogen;
• optionally substituted C1 to C8 alkyl;
• or halogen;
• Z is hydrogen;
• or C1 to C8 alkyl;
• A is CH or N;
• B is CH or N, with the proviso that at least one of A or B is N, and that when A is N, B is CH;
• R1 is hydroxyl;
• optionally substituted C1 to C8 alkyl;
• C2 to C8 alkenyl;
• C2 to C8 alkynyl;
• optionally substituted heterocyclyl;
• optionally substituted heteroaryl;
• or optionally substituted aryl;
• R2 is hydrogen;
• hydroxyl;
• halogen;
• optionally substituted heteroaryl;
• optionally substituted C1 to C8 alkyl;
• —C(O)—Rc;
• —C(O)O—Rd;
• —C(O)C(O)—NH—Rd;
• —C(O)C(O)—O—Rd;
• —C(O)—N(RdRd);
• —C(S)—N(RdRd);
• —C(S)—O—Re;
• —S(O2)—Re;
• —C(NRe)—S—Re;
• or —C(S)—S—Rf;
• Rc is hydrogen;
• optionally substituted amino;
• optionally substituted aryl;
• —C(O)—Rn;
• optionally substituted heterocyclyl;
• heteroaryl;
• thiazoleamino;
• optionally substituted C1 to C8 alkyl;
• cycloalkyl;
• or optionally substituted C2 to C8 alkenyl;
• Rd is at each occurrence independently hydrogen;
• C2 to C8 alkenyl;
• C2 to C8 alkynyl;
• optionally substituted aryl;
• cycloalkyl;
• or optionally substituted C1 to C8 alkyl;
• Re is hydrogen;
• optionally substituted C1 to C8 alkyl;
• optionally substituted cycloalkyl;
• or optionally substituted aryl;
• Rf is optionally substituted C1 to C8 alkyl;
• Rn is hydroxyl;
• C1 to C8 alkoxy;
• amino;
• optionally substituted aryl;
• R3 is hydrogen;
• or —C(O)—Rg;
• and
• Rg is hydroxyl;
• optionally substituted amino;
• optionally substituted heteroaryl;
• or optionally substituted heterocyclyl.

A method for inhibiting or reducing the viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects in a subject in need thereof, comprising administering to the subject an effective amount of a compound having Formula (I):

• or a pharmaceutically acceptable salt, racemate, tautomer or stereoisomer thereof, wherein,
• W is hydrogen;
• or halogen;
• X is hydrogen;
• optionally substituted C1 to C8 alkyl;
• hydroxyl;
• halogen;
• thioether;
• sulfinyl;
• sulfonyl;
• cyano;
• or optionally substituted C1 to C8;
• Y is hydrogen;
• optionally substituted C1 to C8 alkyl;
• or halogen;
• Z is hydrogen;
• or C1 to C8 alkyl;
• A is CH or N;
• B is CH or N, with the proviso that at least one of A or B is N, and that when A is N, B is CH;
• R1 is hydroxyl;
• optionally substituted C1 to C8 alkyl;
• C2 to C8 alkenyl;
• C2 to C8 alkynyl;
• optionally substituted heterocyclyl;
• optionally substituted heteroaryl;
• or optionally substituted aryl;
• R2 is hydrogen;
• hydroxyl;
• halogen;
• optionally substituted heteroaryl;
• optionally substituted C1 to C8 alkyl;
• —C(O)—Re;
• —C(O)O—Rd;
• —C(O)C(O)—NH—Rd;
• —C(O)C(O)—O—Rd;
• —C(O)—N(RdRd);
• —C(S)—N(RdRd);
• —C(S)—O—Re;
• —S(O2)—Re;
• —C(NRe)—S—Re;
• or —C(S)—S—Rf;
• Rc is hydrogen;
• optionally substituted amino;
• optionally substituted aryl;
• —C(O)—Rn;
• optionally substituted heterocyclyl;
• heteroaryl;
• thiazoleamino;
• optionally substituted C1 to C8 alkyl;
• cycloalkyl;
• or optionally substituted C2 to C8 alkenyl;
• Rd is at each occurrence independently hydrogen;
• C2 to C8 alkenyl;
• C2 to C8 alkynyl;
• optionally substituted aryl;
• cycloalkyl;
• or optionally substituted C1 to C8 alkyl;
• Re is hydrogen;
• optionally substituted C1 to C8 alkyl;
• optionally substituted cycloalkyl;
• or optionally substituted aryl;
• Rf is optionally substituted C1 to C8 alkyl;
• Rn is hydroxyl;
• C1 to C8 alkoxy;
• amino;
• optionally substituted aryl;
• R3 is hydrogen;
• or —C(O)—Rg;
• and
• Rg is hydroxyl;
• optionally substituted amino;
• optionally substituted heteroaryl;
• or optionally substituted heterocyclyl.