US 2013/0171097 A1 · METHOD FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF GLUCOCORTICOID-INDUCED OSTEOPOROSIS

Abstract

The present invention relates to a method for the prophylactic and/or therapeutic treatment of glucocorticoid induced osteoporosis comprising maintaining or restoring AP-1 activity or AP-1-mediated effects, for example by LIF treatment. The method may additionally comprise a method for the treatment of a medical condition associated with inflammation comprising inhibition of NF-KB activity, for example by glucocorticoid (GC) treatment. The present invention therefore also relates to a method for the treatment and/or prevention of glucocorticoid induced osteoporosis comprising the administration of an effective amount of LIF to a subject, preferably in combination with GC treatment.

Claims22

Dependent claims

A method for prophylactic or therapeutic treatment of glucocorticoid induced osteoporosis comprising

maintaining or restoring AP-1 activity or one or more AP-1-mediated effects to an level effective for treating glucocorticoid induced osteoporosis in a subject in need of said treatment.

Dependencies are inferred from the claim text.

Facts

Application

13/707,823Filed 7 Dec 2012

Priority

7 Jun 2010

Published

4 Jul 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 38/204
Interleukins [IL]: il-6
A61K 31/00
Medicinal preparations containing organic active ingredients
A61K 31/216
Of carboxylic acids: of acids having aromatic rings, e.g. benactizyne, clofibrate
A61K 31/222
Of acyclic acids, e.g. pravastatin: with compounds having aromatic groups, e.g. dipivefrine, ibopamine

Method for the prophylactic or therapeutic treatment of glucocorticoid-induced osteoporosis

Life of this patent

Method for the prophylactic or therapeutic treatment of glucocorticoid-induced osteoporosis

Life of this patent

Abstract

Claims22