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US 2013/0171073 A1Published application
Treatment of pituitary corticotroph tumors using r-roscovitine
AssigneeCedars-Sinai Medical Center
InventorsShlomo Melmed, Ning-Ai Liu
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Abstract
The present invention describes methods of treating a pituitary tumor, methods of suppressing ACTH and/or corticosterone levels in an ACTH-secreting pituitary adenoma, methods of inhibiting the growth of an ACTH-secreting pituitary adenoma and methods of treating Cushing's disease. These methods can include providing a composition comprising R-roscovitin or a salt thereof and administering the composition to a mammalian subject in need thereof.
Claims16
A method, comprising:
- providing a composition comprising a selective CDK/cyclin inhibitor;
- and
- administering a therapeutically effective amount of the composition to a mammalian subject in need of treating a pituitary tumor, suppressing ACTH and/or corticosterone levels in a ACTH-secreting pituitary adenoma, inhibiting the growth of an ACTH-secreting pituitary adenoma, or treating Cushing's disease to treat the pituitary tumor, suppress the ACTH and/or corticosterone levels in a ACTH-secreting pituitary adenoma, inhibit the growth of an ACTH-secreting pituitary adenoma, or treat Cushing's disease.
A kit, comprising:
- a quantity of a composition comprising a selective CDK/cyclin inhibitor;
- and
- instructions for administering a therapeutically effective amount of the composition to a mammalian subject in need of treating a pituitary tumor, suppressing ACTH and/or corticosterone levels in a ACTH-secreting pituitary adenoma, inhibiting the growth of an ACTH-secreting pituitary adenoma, or treating Cushing's disease to treat the pituitary tumor, suppress the ACTH and/or corticosterone levels in a ACTH-secreting pituitary adenoma, inhibit the growth of an ACTH-secreting pituitary adenoma, or treat Cushing's disease.
A method, comprising:
- providing a transgenic zebrafish;
- administering a test compound to the transgenic zebrafish;
- and
- assessing the effects of the test compound on the transgenic zebrafish,
- wherein a test compound that inhibits tumor growth is identified as a compound capable of inhibiting the growth of an ACTH-secreting pituitary adenoma, and/or capable of treating Cushing Disease, or
- a test compound that inhibits pttg expression is identified as a compound capable of inhibiting the growth of an ACTH-secreting pituitary adenoma, and/or capable of treating Cushing Disease.
3 more elements
Dependencies are inferred from the claim text.