Humanized Anti-Factor D Antibodies And Uses Thereof
AssigneeGenentech, Inc.
InventorsLing-Ling An, Sek Chung Fung, Robert F. Kelley, Henry b. Lowman, Sanjaya Singh, Herren Wu
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Abstract
The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
Claims21
1-37. (canceled)
A method for detecting Factor D in a diagnostic assay comprising binding an anti-Factor D antibody or an anti-Factor D antibody fragment thereof to Factor D, wherein the antibody comprises a variable light chain comprising a CDR-L 1 having the sequence of SEQ ID NO:
- 16;
- a CDR-L2 having the sequence of SEQ ID NO:
- 17, 21 or 24, and a CDR-L3 having the sequence of SEQ ID NO:
- 18, 19 or 22, wherein the variable light chain does not comprise the sequence of SEQ ID NO:
- 2.
A method for detecting Factor D in a diagnostic assay comprising binding an anti-Factor D antibody or an anti-Factor D antibody fragment thereof to Factor D, wherein the antibody comprises a variable heavy chain comprising a CDR-H1 having the sequence of SEQ ID NO:
- 13, 23 or 25;
- a CDR-H2 having the sequence of SEQ ID NO:
- 14;
- and a CDR-H3 having the sequence of SEQ ID NO:
- 15 or 20, wherein the variable heavy chain does not comprise the sequence of SEQ ID NO:
- 1.
A method for detecting Factor D in a diagnostic assay comprising binding an anti-Factor D antibody or an anti-Factor D antibody fragment thereof to Factor D, wherein the antibody comprises:
- (i) a variable light chain comprising a CDR-L1 having the sequence of SEQ ID NO:
- 16;
- a CDR-L2 having the sequence of SEQ ID NO:
- 17.21 or 24, and a CDR-L3 having the sequence of SEQ ID NO:
- 18, 19 or 22;
- and
- (ii) a variable heavy chain comprising a CDR-H1 having the sequence of SEQ ID NO:
- 13, 23 or 25;
- a CDR-H2 having the sequence of SEQ ID NO:
- 14;
- and a CDR-H3 having the sequence of SEQ ID NO:
- 15 or 20.
- wherein (i) the variable light chain does not comprise the sequence of SEQ ID NO:
- 2;
- or (ii) the variable heavy chain does not comprise the sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.