Polymeric complements to a b-amyloid peptides

A molecularly imprinted polymer (MIP) selective for one or more of β-amyloid (Aβ) peptide isoforms Aβ1-38 (SEQ ID NO:

• 2), Aβ1-39 (SEQ ID NO:
• 3), Aβ1-40 (SEQ ID NO:
• 4), Aβ1-41 (SEQ ID NO:
• 5), Aβ1-42 (SEQ ID NO:
• 6) or Aβ1-43 (SEQ ID NO:
• 7) or a truncated isoform thereof, wherein said MIP has been prepared using a template selected from one or more of C-terminal epitope(s) or N-terminal epitope(s) of Aβ;
• wherein the C-terminal epitope(s) is selected from the group consisting of AβX-38, AβX-39, AβX-40, AβX-41, AβX-42 or AβX-43 or a modified form thereof;
• and the N-terminal epitope(s) is selected from the group consisting of (Aβ1-Y) or (Aβ2-Y) or a modified form thereof;
• wherein X is an integer between 23 and 40 and Y is an integer between 3 and 15.