Mapping in vivo eosinophil activation in eosinophilic esophagitis
AssigneeUniversity of Utah Research Foundation
InventorsLeonard Franklin Pease, III, Kathryn Peterson, Gerald J. Gleich
Life of this patent
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Abstract
Provided are compositions and methods for diagnosing eosinophilic esophagitis in a mammalian subject. Further provided are methods of monitoring the course of eosinophilic esophagitis in a subject diagnosed with the disease.
Claims26
A method of producing a three-dimensional map of an esophagus in a subject, comprising detecting an eosinophil protein in the lumen of the esophagus in a subject, comprising administering to the subject a labeled antibody directed against an eosinophil protein under conditions wherein the labeled antibody can bind to the eosinophil protein, and detecting a labeled antibody/eosinophil protein complex in the lumen of the esophagus, whereby detecting the labeled antibody/eosinophil protein complex in the lumen of the esophagus produces a three-dimensional map of the esophagus in the subject.
15-28. (canceled)
30-52. (canceled)
The method of claim 44, wherein the antibody/eosinophil protein complex is detected by MRI analysis.
The method of claim 44, wherein the molecular map can be a two- or three-dimensional molecular map.
55-64. (canceled)
A method of detecting eosinophilic degranulation in a subject, comprising detecting a granule protein in a subject, comprising administering to the subject a labeled antibody directed against a granule protein under conditions wherein the labeled antibody can bind to the granule protein, and detecting a labeled antibody/granule protein complex, whereby detecting the labeled antibody/granule protein complex indicates the presence of eosinophilic degranulation in the subject.
(canceled)
The method of claim 44, wherein the molecular map of the esophagus is used to diagnose eosinophilic esophagitis in a subject.
Dependencies are inferred from the claim text.