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AssigneeInstitut Pasteur
InventorsStewart COLE, Stéphen Gordon, Roland Buchrieser-Brosch, Alain Billault, Thierry Garnier
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The invention concerns the isolation of nucleotide and peptide sequences in particular for differentiating, in diagnostic terms, an immunisation resulting from BCG vaccination of an infection by M. tuberculosis. Said sequences are either M. bovis BCG/M. bovis specific or M. tuberculosis specific. The invention also concerns a method for detecting said sequences, a method for detecting antibodies generated by the products expressing said sequences as well as kits for implementing said methods. Finally, the invention concerns novel vaccines.
1-25. (canceled)
An isolated nucleic acid which is a primer or molecular hybridization probe comprising sequence from M. tuberculosis, wherein the M. tuberculosis sequence in the primer or probe consists of a sequence of ORF Rv2075c which is absent from M. microti strain OV254 due to deletion of RD9.
A method of characterizing a nucleic acid of a mycobacterium in a biological sample, comprising:
Dependencies are inferred from the claim text.