# US 2013/0158480 A1 · Indwelling heat exchange catheter and method of using same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2013/0158480 A1 - Document ID: US20130158480A1 - Status: Published application - Kind: A1 - Application number: 13/771,447 - Filed: 2013-02-20 - Published: 2013-06-20 - Earliest claimed: 1998-04-21 - Assignees: The Regents of the University of California; Zoll Circulation, Inc. - Inventors: Wayne A. Noda; Mike L. Jones; Scott M. Evans; Blair D. Walker; William J. Worthen; Yves Pierre Gobin - Web page: https://patentgrep.com/patent/US20130158480A1 ## CPC - A61F 7/12: Devices for heating or cooling internal body cavities - A61F 7/123: {using a flexible balloon containing the thermal element} - A61M 5/44: having means for cooling or heating the devices or media - A61P 7/12: Antidiuretics, e.g. drugs for diabetes insipidus (ADH A61P5/10) - A61B 2018/00011: {with fluids} - A61F 2007/0054: {with a closed fluid circuit, e.g. hot water} - A61F 2007/126: {for invasive application, e.g. for introducing into blood vessels} - A61M 1/369: {Temperature treatment} - A61M 25/0009: {Making of catheters or other medical or surgical tubes} - A61M 25/1011: {Multiple balloon catheters} - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system. ## Claims ### Claim at position 1 1-63. (canceled) ### Claim 64 A heat exchange catheter comprising: at least one lumen configured for fluid communication with at least first and second heat exchange elements for circulating heat exchange fluid through the heat exchange elements to exchange heat with blood of a patient when at least a portion of the catheter is positioned in a bloodstream of the patient without the heat exchange fluid entering the bloodstream of a patient; wherein each of the first and second heat exchange elements are externally fluted along at least a respective segment thereof, wherein body fluid outward of a heat exchange element cannot flow to a long axis defined by a fluted configuration of the heat exchange element; wherein the first and second heat exchange elements are separated from each other by a flex region that is not externally fluted in a spiral configuration on a segment thereof. ### Claim 65 (depends on 64) The catheter of claim 64, wherein the heat exchange elements are axially arranged relative to each other. ### Claim 66 (depends on 64) The catheter of claim 64, wherein the catheter is provided with distal metal structure. ### Claim 67 (depends on 65) The catheter of claim 65, wherein the catheter is provided with distal metal structure. ### Claim 68 (depends on 64) The catheter of claim 64, comprising an anti-thrombogenic coating on at least a portion of the catheter. ### Claim 69 Apparatus comprising: at least one heat exchange fluid lumen; and at least one fluted heat exchange element communicating with the lumen such that heat exchange fluid circulates through the heat exchange element to exchange heat with blood of a patient when the heat exchange element is positioned in a bloodstream of the patient, the heat exchange fluid not entering the bloodstream; wherein first and second fluted heat exchange elements are separated from each other by a flex region, the flex region not being configured like the heat exchange elements. ### Claim 70 (depends on 69) The catheter of claim 69, wherein the heat exchange elements are axially arranged with respect to each other. ### Claim 71 (depends on 69) The catheter of claim 69, wherein the catheter is provided with distal metal structure. ### Claim 72 (depends on 69) The catheter of claim 69, comprising an anti-thrombogenic coating on at least a portion of the apparatus. ### Claim 73 A heat exchange catheter comprising: at least one heat exchange fluid lumen configured for fluid communication with at least one heat exchange element distally located on the catheter for circulating heat exchange fluid through the heat exchange element to exchange heat with blood of a patient when the catheter is positioned in a bloodstream of the patient without the heat exchange fluid entering the bloodstream of the patient; wherein the heat exchange element is a first heat exchange element and the catheter includes a second heat exchange element, the heat exchange elements defining fluted configurations and being separated from each other by a flex region that is not configured like the heat exchange elements. ### Claim 74 (depends on 73) The catheter of claim 73, wherein at least one heat exchange element is externally fluted in a spiral configuration along at least a segment thereof, wherein body fluid laterally outward of the heat exchange element cannot flow between the heat exchange element and a long axis defined by the spiral configuration of the heat exchange element. ### Claim 75 (depends on 73) The catheter of claim 73, wherein the heat exchange elements are axially arranged such that the catheter can bend and flex when placed in a curved vasculature and is not as rigid, stiff and inflexible by comparison to a single heat exchange element catheter. ### Claim 76 (depends on 73) The catheter of claim 73, comprising an anti-thrombogenic coating on at least a portion of the catheter. ### Claim 77 (depends on 75) The catheter of claim 75, wherein the heat exchange elements extend axially along a surface of the catheter. ### Claim 78 (depends on 73) The catheter of claim 73, comprising a hydrophilic or hydrophobic coating on at least a portion of the catheter. ### Claim 79 (depends on 73) The catheter of claim 73, wherein the heat exchange element is configured to enhance heat exchange by being configured with at least one irregular surface next to which blood and/or heat exchange fluid flows. ### Claim 80 (depends on 79) The catheter of claim 79, wherein the irregular surface is spiral-shaped. ### Claim 81 (depends on 79) The catheter of claim 79, wherein the irregular surface is established by structure defining peaks and valleys. ### Claim 82 (depends on 79) The catheter of claim 79, wherein the irregular surface is established by ridges. ### Claim 83 (depends on 73) The catheter of claim 73, wherein a single heat exchange element is formed with plural flutes.