# US 2013/0158472 A1 · Subcutaneous Controlled Delivery System For The Topical Administration Of Drugs, Biological Agents Or Therapeutic Agents To Targeted Areas Within The Body

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- Number: US 2013/0158472 A1
- Document ID: US20130158472A1
- Status: Published application
- Kind: A1
- Application number: 13/716,826
- Filed: 2012-12-17
- Published: 2013-06-20
- Earliest claimed: 2011-12-16
- Inventors: Jaishankar Raman
- Web page: https://patentgrep.com/patent/US20130158472A1

## CPC

- A61M 39/0208: {Subcutaneous access sites (implantable infusion devices A61M5/14276; transcutaneous access sites A61M39/0247)}
- A61K 9/0024: {Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L)}
- A61M 2205/04: implanted
- A61M 2205/3317: Electromagnetic, inductive or dielectric measuring means
- A61M 2205/3584: using modem, internet or Bluetooth®
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention is directed to a subcutaneous controlled delivery device that provides for a refillable reservoir port, a release mechanism and tubing that operably connects the reservoir port to the release mechanism. Such a device is capable of being implanted under the dermis of the skin and allows for the controlled release of drugs, biological agents or therapeutic agents to a target site of interest in the body for treatment.

## Claims

### Claim 1

A subcutaneous delivery device comprising:
a reservoir port;
a release mechanism; and
tubing that operably connects the reservoir port to the release mechanism to administer drugs, biological agents or therapeutic agents to a target treatment site in a controlled manner.

### Claim 2 (depends on 1)

The device of claim 1, wherein the reservoir port is implanted in a small area near the dermis.

### Claim 3 (depends on 1)

The device of claim 1, wherein the reservoir port has a membrane through which the agents are injected.

### Claim 4 (depends on 1)

The device of claim 1, wherein the tubing transports the agent from the reservoir port to the site of treatment.

### Claim 5 (depends on 1)

The device of claim 1, wherein the release mechanism comprises macro-, micro, or nanopores for local treatment.

### Claim 6 (depends on 1)

The device of claim 1, wherein the release mechanism comprises polymeric membranes or silicon based porous surfaces.

### Claim 7 (depends on 6)

The device of claim 6, wherein the polymeric membranes are interfaced with 3-dimensional mechanical tissue engineering constructs for release and sustenance of stem cells at the target site for treatment.

### Claim 8 (depends on 1)

The device of claim 1, wherein the release mechanism is customizable depending on the desired treatment.

### Claim 9 (depends on 1)

The device of claim 1, wherein the reservoir port includes a wireless transmitter/receiver to relay data between the device and a control unit located outside the body.

### Claim 10 (depends on 9)

The device of claim 9, wherein the control unit triggers operation of the release mechanism and/or reservoir port.

### Claim 12 (depends on 1)

The device of claim 1, wherein the release mechanism at the target site includes a sensor for relying information from the target site to the control unit.