# US 2013/0158459 A1 · Device for setting up a dilution measurement site

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- Number: US 2013/0158459 A1
- Document ID: US20130158459A1
- Status: Published application
- Kind: A1
- Application number: 13/764,967
- Filed: 2013-02-12
- Published: 2013-06-20
- Earliest claimed: 2006-01-30
- Assignees: Pulsion Medical Systems AG
- Inventors: Oliver GOEDJE; Thomas THALMEIER; Matthias BOHN
- Web page: https://patentgrep.com/patent/US20130158459A1

## CPC

- A61M 1/30: Single needle dialysis {; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis}
- A61B 5/028: by thermo-dilution
- A61M 1/367: {Circuit parts not covered by the preceding subgroups of group A61M1/3621}
- A61M 2230/20: Blood composition characteristics
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A device sets up a dilution measurement site on a hemodialyzer for determining the filling status of a dialysis patient during dialysis treatment, by dilution measurements. The arterial connection piece is connected with an arterial fistula needle, and the venous connection piece is connected with a venous fistula needle. The venous connection piece has an injection channel through which a bolus required to perform a dilution measurement can be injected into the blood, which flows through the venous connection piece coming from the hemodialyzer, in the direction of the venous blood vessel access. The arterial connection piece has a sensor measuring the temperature of the blood flowing through the venous connection piece coming from the arterial blood vessel access, in the direction of the hemodialyzer.

## Claims

### Claim 1

Method of setting up a dilution measurement site on a hemodialyzer, said method including the steps of
connecting an arterial connection piece to a hemodialyzer input,
connecting said arterial connection piece to an arterial blood vessel access,
installing at least one of a sensor for measuring the temperature of blood to be dialyzed and a sensor for measuring an indicator concentration in blood to be dialyzed,
connecting a venous connection piece, having an injection channel for injecting a bolus into dialyzed blood that flows through the venous connection piece, to a hemodialyzer output, and
connecting said venous connection piece to a venous blood vessel access.

### Claim 2 (depends on 1)

Method according to claim 1, wherein, for said arterial connection piece, an arterial connection piece is used into which at least one of said sensor for measuring the temperature of blood to be dialyzed and said sensor for measuring an indicator concentration in blood to be dialyzed is integrated.

### Claim 3

Method of carrying out thermodilution measurements on the cardiovascular system of a dialysis patient, said method including the steps of
setting up a dilution measurement site on a hemodialyzer by connecting an arterial connection piece to a hemodialyzer input, connecting said arterial connection piece to an arterial blood vessel access, installing a sensor for measuring the temperature of blood to be dialyzed, connecting a venous connection piece, having an injection channel for injecting a bolus into dialyzed blood that flows through the venous connection piece, to a hemodialyzer output, and connecting said venous connection piece to a venous blood vessel access,
injecting said bolus into said dialyzed blood through said injection channel, wherein said bolus has a temperature different from said dialyzed blood,
acquiring at least one variable characterizing said bolus injection, said at least one variable including at least one of temperature of said bolus injected, amount of said bolus injected and duration of said injection of said bolus,
measuring, using said sensor, the temperature of the blood to be dialyzed over time,
evaluating a transpulmonary diffusion measurement, in that at least one hemodynamic parameter is determined proceeding from the measured temperature of the blood to be dialyzed over time and the at least one variable characterizing said bolus injection.

### Claim 4 (depends on 3)

Method according to claim 3, wherein, for said arterial connection piece, an arterial connection piece is used into which said sensor for measuring the temperature of the blood to be dialyzed is integrated.