# US 2013/0158449 A1 · Double stimulation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2013/0158449 A1 - Document ID: US20130158449A1 - Status: Published application - Kind: A1 - Application number: 13/714,634 - Filed: 2012-12-14 - Published: 2013-06-20 - Earliest claimed: 2011-12-16 - Assignees: Chordate Medical AB - Inventors: Jan-Erik JUTO; Fredrik JUTO; Victor KRONESTEDT; William HOLM - Web page: https://patentgrep.com/patent/US20130158449A1 ## CPC - A61H 9/0078: {with intermittent or alternately inflated bladders or cuffs (mattresses for preventing bed-sores with alternated pressurized chambers A61G7/05776)} - A61H 1/00: Apparatus for passive exercising (A61H5/00 takes precedence); Vibrating apparatus; Chiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones - A61H 21/00: Massage devices for cavities of the body {, e.g. nose, ears and anus (for the genitals A61H19/00); Vibration or percussion related aspects A61H23/00} - A61H 23/02: with electric or magnetic drive - A61H 23/04: with hydraulic or pneumatic drive {(hydraulic or Pneumatic massages, A61H9/00; underwater massages, A61H33/00)} - A61H 2201/0103: inflatable - A61H 2201/5071: Pressure sensors - A61H 2205/023: Nose - A61H 2230/045: used as a control parameter for the apparatus - A61H 2230/065: used as a control parameter for the apparatus - A61H 2230/105: used as a control parameter for the apparatus - A61H 2230/505: used as a control parameter for the apparatus - G16H 20/30: relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising - A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract A method of vibration treatment in at least one nasal cavity of a human subject is provided. The method comprises the steps of: inserting a first stimulation member in a first nasal cavity; inserting a second stimulation member in a second nasal cavity; securing the first and second stimulation members such that the stimulation members are in fixed positions within the nasal cavities prior to vibration stimulation; arranging each of the first and second stimulation members to abut against tissue within each of the first and second nasal cavities at a first and second pressure; and imparting vibrations to tissue in at least one of the first and second nasal cavities via at least one of the first and second stimulation members. ## Claims ### Claim 1 A method of vibration treatment in at least one nasal cavity of a human subject comprising the steps of: a) inserting a first stimulation member in a first nasal cavity; b) inserting a second stimulation member in a second nasal cavity; c) securing the first and second stimulation members such that the stimulation members are in fixed positions within the nasal cavities prior to vibration stimulation; d) arranging each of the first and second stimulation members to abut against tissue within each of the first and second nasal cavities at a first and second pressure; and e) imparting vibrations to tissue in at least one of the first and second nasal cavities via at least one of the first and second stimulation members. ### Claim 2 (depends on 1) The method of vibration treatment according to claim 1, wherein a frequency of the vibrations imparted to the at least one nasal cavity is selected from a range of between 40 Hz and 100 Hz. ### Claim 3 (depends on 1) The method of vibration treatment according to claims 1, wherein said step e) further comprises the step of imparting vibrations at a first frequency to the first nasal cavity and imparting vibrations at a second frequency to the second nasal cavity. ### Claim 4 (depends on 3) The method according to claim 3, wherein a difference between the frequencies imparted by the first stimulation member and the second stimulation member is in the range of 5-30 Hz. ### Claim 5 (depends on 1) The method of vibration treatment according to claim 1, wherein vibrations are imparted to one of the first and second nasal cavities at a time. ### Claim 6 (depends on 1) The method according to claim 1, wherein each of the first and second stimulation members is arranged to abut against the tissue of each of the first and second nasal cavities at at least one pressure selected from a range of between approximately 20 mbar and 120 mbar. ### Claim 7 (depends on 1) The method according to claim 1, wherein an amplitude of the vibrations imparted to the at least one nasal cavity is selected from the range of between approximately 0.05 mm and 20 mm. ### Claim 8 (depends on 1) The method of vibration treatment according to claim 1, further comprising the step of: f) measuring a bodily response to the vibration treatment. ### Claim 9 (depends on 8) The method of vibration treatment according to claim 8, wherein the bodily response is a pressure exerted by the tissue on one of the first and second stimulation members in one of the first and second nasal cavities. ### Claim 10 (depends on 8) The method of vibration treatment according to claim 8, wherein the measure of a bodily response is selected from the group consisting of: oxygen consumption as measured by fMRI, metabolic activity as measured by PET, magnetic signals as measured by MEG, electrical signals as measured with EEG, electrocardiogram (ECG), pain sensation, heart rate, pupil size, body temperature, photoplethysmogram, and blood pressure. ### Claim 11 (depends on 8) The method according to claim 8, further comprising the step of storing data time samples comprising the measured bodily response and at least one associated vibration stimulation parameter. ### Claim 12 (depends on 11) The method of vibration treatment according to claim 11, wherein the at least one vibration stimulation parameter is selected from the group consisting of: a frequency of the vibrations imparted by one of or both of the first and second stimulation member(s); an amplitude of the vibrations imparted by one of or both of the first and second stimulation member(s); a pressure at which one of or both of the first and second stimulation member(s) abut(s) against the tissue of one of or both of the first and second nasal cavity(s); a difference between the frequencies of the vibrations imparted by the first and second stimulation members; a difference between the amplitudes of the vibrations imparted by the first and second stimulation members; and a difference between the pressures at which the first and second stimulation members abut against the tissue of the first and second nasal cavities; and a vibration stimulation duration. ### Claim 13 (depends on 12) The method of vibration treatment according to claim 12, further comprising the steps of: comparing a previously obtained measure of the bodily response with a later measure of the bodily response; and adjusting at least one of a vibration stimulation parameter and a stimulation cavity if the difference between the later obtained measure and the previously obtained measure lies within a threshold tolerance. ### Claim 14 (depends on 12) The method of vibration treatment according to claim 12, further comprising the steps of: comparing a previously obtained measure of the bodily response with a later measure of the bodily response; and adjusting at least one of a vibration stimulation parameter and a stimulation cavity if a desired value of the measure is not approached. ### Claim 15 (depends on 13) The method according to claim 13, wherein the step of adjusting comprises one of: a randomly selected adjustment; an adjustment calculated form a pre-programmed look up table comprising correlations between desired changes in the measure and at least one vibration stimulation parameter; and an adjustment calculated based on correlations between desired changes in the measure and at least one vibration stimulation parameter as derived from previously stored data time samples. ### Claim 16 (depends on 15) The method according to claim 15, wherein the desired value of the measure of the bodily response is proportional to a measure of the bodily response previously obtained during the vibration stimulation, or is set to a fraction of an initial measured value or to a pre-programmed desired value. ### Claim 17 (depends on 1) The method of vibration treatment according to claim 1, wherein the human subject is suffering from at least one of a disease associated with a dysfunction of the sphenopalatine ganglion, a disease associated with a dysfunction of the hypothalamus, cluster headache, migraine, heart arrhythmia, or hypertension. ### Claim 18 A device for vibration stimulation in at least one nasal cavity of a human subject, comprising: a first stimulation member arranged to be introducible into a first nasal cavity, to be expanded within the first nasal cavity and to abut against tissue in the first nasal cavity; a first expansion member arranged to expand the first stimulation member; the first expansion member comprising a first tubular structure arranged at least partly within the first stimulation member, wherein the first tubular structure is provided with a plurality of openings arranged for fluid communication with the stimulation member; a second stimulation member arranged to be introducible into a second nasal cavity, to be expanded within the second nasal cavity and to abut against tissue in the second nasal cavity; and a second expansion member arranged to expand the second stimulation member; the second expansion member comprising a second tubular structure arranged at least partly within the second stimulation member, wherein the second tubular structure is provided with a plurality of openings arranged for fluid communication with the second stimulation member; wherein at least one of the first and second stimulation members is arranged to impart vibrations to the tissue in at least one of the first and second nasal cavities. ### Claim 19 (depends on 1, 18) The method according to claim 1, wherein the first and second stimulation members are comprised in a device according to claim 18.