# US 2013/0158431 A1 · Sample collection system and method for use thereof

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- Number: US 2013/0158431 A1
- Document ID: US20130158431A1
- Status: Published application
- Kind: A1
- Application number: 13/663,036
- Filed: 2012-10-29
- Published: 2013-06-20
- Earliest claimed: 1998-11-16
- Inventors: Jack L. Aronowitz
- Web page: https://patentgrep.com/patent/US20130158431A1

## CPC

- A61J 1/05: for collecting, storing or administering blood, plasma or medical fluids {(multiple bags systems for separating or storing blood components A61M1/0209); Infusion or perfusion containers}
- A61B 10/0051: {for taking saliva or sputum samples (devices for receiving spittle A61J9/00)}
- B01L 3/5082: {Test tubes per se}
- G01N 1/405: {by adsorption or absorption}
- A61B 10/0096: {Casings for storing test samples (A61B10/0038, A61B10/0045 take precedence; preservation of living parts of the human or animal body A01N1/10; containers for retaining a material to be analysed B01L3/50; containers for enzymology or microbiology C12M1/16; swab-sampler being part of enzymology or microbiology container C12M1/30)}
- Y10T 436/255: including use of a solid sorbent, semipermeable membrane, or liquid extraction
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A sample collection system capable of collecting, storing and dispensing a liquid sample is disclosed. The collection system includes a collector composed of a material which has the unique ability to express constituents of interest at levels which are more concentrated than their levels in the fluid samples from which they are expressed, where the expressed highly concentrated sample can then be used with modern rapid screening/testing protocols, such as solid phase assays, to test for the constituents of interest. Thus, it is now possible to obtain analytes of interest, such as the HIV protein antibodies, from saliva samples at concentrations that are representative of that found in serum or plasma. The collector is sized and shaped to fit within a recovery container, which, in turn, is sized and shaped to fit within a collection tube. The recovery container includes an aperture which does not permit passage of fluid under ambient conditions, but facilitates transfer thereof when subject to pressure. An optional channel within the collection tube facilitates dispensing of the sample for further processing.

## Claims

### Claim 1

A collector device for use with a saliva sample collection system, said collector device comprising
a closure for cooperating with a collecting container, and
a collector connected to said closure for insertion into the collecting container when the closure is connected to the collecting container, wherein said collector is capable of collecting and storing a saliva sample including constituents of interest present in the saliva sample when said collector is strategically positioned in the mouth of an individual for a sufficient period of time, and wherein said collector is capable of expressing from the saliva sample constituents of interest in concentration levels which are representative of the concentrations for the constituents of interest found in serum or plasma.

### Claim 2

A collection system for collecting, storing and dispensing a fluid sample including constituents of interest, said collection system comprising:
a collector;
a recovery container; and
a collection tube;
said recovery container shaped and sized to seat within said collection tube, said recovery container occupying less than total volume of said collection tube;
wherein said collector is sized and shaped to removably fit within said recovery container; and
wherein said collector is capable of collecting and storing said sample; and
wherein said collector is further capable of expressing therefrom constituents of interest in concentrations levels which are more concentrated than their concentration levels in the fluid sample from which they are expressed.

### Claim 3

A method for collecting and storing a fluid sample containing an analyte of interest and expressing the analyte therefrom, said method comprising the step of:
collecting the fluid sample via use of a collector capable of concentrating the analyte in a concentration level which is more concentrated than its concentration level in the fluid sample from which it is expressed.