# US 2013/0158342 A1 · Photochemical tissue bonding > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2013/0158342 A1 - Document ID: US20130158342A1 - Status: Published application - Kind: A1 - Application number: 13/543,137 - Filed: 2012-07-06 - Published: 2013-06-20 - Earliest claimed: 2000-02-11 - Assignees: The General Hospital Corporation - Inventors: Barbara Chan; Timothy Shane Johnson; Irene E. Kochevar; Mark Randolph; Robert W. Redmond; Jonathan M. Winograd - Web page: https://patentgrep.com/patent/US20130158342A1 ## CPC - A61B 17/11: for performing anastomosis; Buttons for anastomosis - A61F 9/0079: {using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves} - A61F 9/0081: {Transplantation} - A61L 24/001: {Use of materials characterised by their function or physical properties} - A61N 5/062: {Photodynamic therapy, i.e. excitation of an agent} - A61B 2017/00508: {using laser} - A61B 2017/00517: {using laser} - A61F 9/00821: {for coagulation} - A61F 2009/00842: {Permanent Structural Change [PSC] in index of refraction; Limit between ablation and plasma ignition} - A61F 2009/00853: {Laser thermal keratoplasty or radial keratotomy} - A61F 2009/00872: {Cornea} - A61F 2009/00887: {Cataract} - A61L 2430/32: for nerve reconstruction - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Photochemical tissue boding methods for bonding neural tissues include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair, neural repair, blood vessel repair and corneal repair. ## Claims ### Claim at position 1 1-43. (canceled) ### Claim 44 A method for adhering blood vessel tissue in a subject, comprising: contacting an outer surface of a proximal vessel and an inner surface of a distal vessel with a photosensitizer agent; folding the distal vessel back to form a distal cuff; apposing the proximal vessel and the distal vessel; everting the distal cuff over the proximal vessel to form an overlap region; and applying electromagnetic energy to the tissue-photosensitizer complex in a manner effective to bond the tissues, thereby creating a tissue seal between the blood vessel tissue. ### Claim 45 (depends on 44) The method of claim 44, wherein prior to contacting the proximal vessel with the distal vessel, the vessels are mounted over a cylindrical support. ### Claim 46 (depends on 45) The method of claim 45, wherein the cylindrical support is a glass rod. ### Claim 47 (depends on 44) The method of claim 44, further comprising applying at least one suture between the vessels before applying the electromagnetic energy. ### Claim 48 (depends on 44) The method of claim 44, wherein the electromagnetic energy is applied externally around the circumference of the overlap region. ### Claim 49 (depends on 44) The method of claim 44, wherein the electromagnetic energy is applied internally around the interior of the overlap region. ### Claim 50 (depends on 44) The method of claim 44, wherein the photosensitizer agent is selected from the group consisting of xanthene, pyridine, phenothiazine, cyanine, flavin, and porphyrin. ### Claim 51 (depends on 44) The method of claim 44, wherein the photosensitizer agent is Rose Bengal. ### Claim 52 (depends on 44) The method of claim 44, wherein the method occurs ex vivo. ### Claim 53 (depends on 44) The method of claim 44, wherein the method occurs in vivo in the subject. ### Claim 54 (depends on 44) The method of claim 44, wherein the subject is a human. ### Claim 55 A method for adhering blood vessel tissue in a subject, comprising: placing a first blood vessel tissue and second blood vessel tissue in a conduit; contacting the first blood vessel tissue and second blood vessel tissue with at least one photosensitizer agent to form a tissue-photosensitizer complex; and applying electromagnetic energy to the tissue-photosensitizer complex in a manner effective to bond the tissues, thereby creating a tissue seal between the blood vessel tissues and the conduit. ### Claim 56 (depends on 55) The method of claim 55, wherein the conduit comprises collagen. ### Claim 57 (depends on 55) The method of claim 55, wherein the conduit is formed from a synthetic absorbable polymer. ### Claim 58 (depends on 55) The method of claim 55, wherein the conduit is formed from PGA. ### Claim 59 (depends on 55) The method of claim 55, wherein the conduit is formed from silicone. ### Claim 60 (depends on 55) The method of claim 55, wherein the electromagnetic energy is applied externally around the circumference of the blood vessel tissue. ### Claim 61 (depends on 55) The method of claim 55, wherein the electromagnetic energy is applied internally around the interior of the blood vessel tissue. ### Claim 62 (depends on 55) The method of claim 55, wherein the photosensitizer agent is selected from the group consisting of xanthene, pyridine, phenothiazine, cyanine, flavin, and porphyrin. ### Claim 63 (depends on 55) The method of claim 55, wherein the photosensitizer agent is Rose Bengal. ### Claim 64 (depends on 55) The method of claim 55, wherein the method occurs ex vivo. ### Claim 65 (depends on 55) The method of claim 55, wherein the method occurs in vivo in the subject. ### Claim 66 (depends on 55) The method of claim 55, wherein the subject is a human.