# US 2013/0158293 A1 · Cancer heat therapy-enhancing agent

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- Number: US 2013/0158293 A1
- Document ID: US20130158293A1
- Status: Published application
- Kind: A1
- Application number: 13/820,303
- Filed: 2011-09-12
- Published: 2013-06-20
- Earliest claimed: 2010-09-14
- Assignees: SBI Pharmaceuticals Co., Ltd.; Tokyo University of Agriculture Educational Corporation
- Inventors: Taku Chibazakura; Tohru Tanaka; Kiwamu Takahashi; Motowo Nakajima; Fuminori Abe
- Web page: https://patentgrep.com/patent/US20130158293A1

## CPC

- C07C 229/22: the carbon skeleton being further substituted by oxygen atoms
- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A61P 35/00: Antineoplastic agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided is an enhancer for cancer thermotherapy not combined with photodynamic therapy. Cancer treatment not combined with photodynamic therapy is made available by using, as an enhancer for cancer thermotherapy, 5-aminolevulinic acids represented by formula (1): R2R1NCH2COCH2CH2COR3 (1) [wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group] or a salt thereof.

## Claims

### Claim 1

An enhancer for cancer thermotherapy not combined with photodynamic therapy, comprising 5-aminolevulinic acids represented by formula (1):
R2R1NCH2COCH2CH2COR3 (1)
[wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group] or a salt thereof.

### Claim 2 (depends on 1)

The enhancer for cancer thermotherapy according to claim 1, wherein the 5-aminolevulinic acids or a salt thereof are not encapsulated inside a lipid membrane or in an internal aqueous phase thereof.