# US 2013/0158252 A1 · Enterosoluble and intestinal-enzyme-biodegradable materials and method for preparing the same

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- Number: US 2013/0158252 A1
- Document ID: US20130158252A1
- Status: Published application
- Kind: A1
- Application number: 13/437,729
- Filed: 2012-04-02
- Published: 2013-06-20
- Earliest claimed: 2011-12-15
- Assignees: Industrial Technology Research Institute
- Inventors: Chien-Pang WU; Jyh-Horng Wu; Shih-Jung Tsai
- Web page: https://patentgrep.com/patent/US20130158252A1

## CPC

- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K 9/48: Preparations in capsules, e.g. of gelatin, of chocolate {(A61K9/0004 takes precedence; bite capsules A61K9/0056)}
- C08B 35/02: Esters
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C08B: POLYSACCHARIDES; DERIVATIVES THEREOF (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages C07H; fermentation or enzyme-using processes C12P19/00; sugar industry C13; production of cellulose D21)

## Abstract

An enterosoluble and intestinal-enzyme-biodegradable material is provided. The enterosoluble and intestinal-enzyme-biodegradable material includes a modified amylopectin, wherein at least one of hydrogen atoms is replaced by —CO—(CH2)n—COOH (n is 2-4) and the modified amylopectin has an acid value of 35-180 mg KOH/g. The disclosure also provides a method for preparing an enterosoluble and intestinal-enzyme-biodegradable material.

## Claims

### Claim 1

An enterosoluble and intestinal-enzyme-biodegradable material comprising a modified amylopectin, wherein at least one of hydrogen atoms is replaced by —CO—(CH2)n—COOH (n is 2-4) and the modified amylopectin has an acid value of 35-180 mg KOH/g.

### Claim 2 (depends on 1)

The enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 1, wherein the modified amylopectin has a relative viscosity of 3.5-16.2 c.p. at 30° C.

### Claim 3 (depends on 1)

The enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 1, wherein the modified amylopectin has a relative viscosity of 1.76-8.3 c.p. at 80° C.

### Claim 4 (depends on 1)

A method for preparing an enterosoluble and intestinal-enzyme-biodegradable material, comprising:
providing an amylopectin;
providing an anhydride derivative; and
mixing the anhydride derivative and the amylopectin to prepare the enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 1.

### Claim 5 (depends on 4)

The method for preparing an enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 4, wherein the anhydride derivative and the amylopectin have a molar ratio of 15:100-100:100.

### Claim 6 (depends on 4)

The method for preparing an enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 4, wherein the anhydride derivative and the amylopectin have a molar ratio of 50:100-100:100.

### Claim 7 (depends on 4)

The method for preparing an enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 4, wherein the anhydride derivative comprises succinic anhydride, glutaric anhydride or adipic anhydride.

### Claim 8 (depends on 4)

The method for preparing an enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 4, wherein the anhydride derivative and the amylopectin are mixed at a temperature of 90-100° C.

### Claim 9 (depends on 4)

The method for preparing an enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 4, wherein the anhydride derivative and the amylopectin are mixed for 10-12 hours.

### Claim 10 (depends on 1)

An enterosoluble and intestinal-enzyme-biodegradable material prepared by the following steps, comprising:
providing an amylopectin;
providing an anhydride derivative; and
mixing the anhydride derivative and the amylopectin to prepare the enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 1.

### Claim 11 (depends on 10)

The enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 10, wherein the anhydride derivative and the amylopectin are mixed at a temperature of 90-100° C.

### Claim 12 (depends on 10)

The enterosoluble and intestinal-enzyme-biodegradable material as claimed in claim 10, wherein the anhydride derivative and the amylopectin are mixed for 10-12 hours.