# US 2013/0158055 A1 · Prevention Of Pancreatic Beta Cell Degeneration

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- Number: US 2013/0158055 A1
- Document ID: US20130158055A1
- Status: Published application
- Kind: A1
- Application number: 13/700,191
- Filed: 2011-05-27
- Published: 2013-06-20
- Earliest claimed: 2010-05-28
- Inventors: Andrew G. Reaume; Michael S. Saporito; Alexander R. Ochman
- Web page: https://patentgrep.com/patent/US20130158055A1

## CPC

- A61K 31/513: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising the compounds or a pharmaceutically acceptable salts thereof that are useful in methods of preventing pancreatic beta cell degeneration or methods of treating a disorder associated with pancreatic beta cell degeneration, such as type I diabetes.

## Claims

### Claim at position 1

1-9. (canceled)

### Claim 10

A method of preventing pancreatic beta cell degeneration, treating a disorder associated with pancreatic beta cell degeneration, or treating or preventing type I diabetes in a mammal comprising administering to the mammal in need thereof an effective amount of a composition comprising a compound of formula:
wherein R1 is an alkyl group; X is a halogen; n is an integer from 0 to 5 and m is 0 or 1, wherein m+n is less than or equal to 5.

### Claim 11 (depends on 10)

The method of claim 10, wherein the alkyl group is methyl and n is 1.

### Claim 12 (depends on 10)

The method of claim 10, wherein the halogen is chlorine and m is 1.

### Claim 13 (depends on 10)

The method of claim 10, wherein R1 is methyl, n is 1, and m is 0.

### Claim 14 (depends on 11)

The method of claim 11, wherein R1 is in the meta position.

### Claim 15 (depends on 10)

The method of claim 10, wherein X is chlorine, n is 0, and m is 1.

### Claim 16 (depends on 15)

The method of claim 15, wherein X is in the meta position.

### Claim 17

A method of preventing pancreatic beta cell degeneration, treating a disorder associated with pancreatic beta cell degeneration, or treating or preventing type I diabetes in a mammal comprising administering to the mammal in need thereof an effective amount of a composition comprising a compound of formula:
wherein R1 is an alkyl group and n is an integer from 0 to 5.

### Claim 18 (depends on 17)

The method of claim 17, wherein R1 is methyl, n is 1.

### Claim 19 (depends on 17)

The method of claim 17, wherein R1 is in the meta position.

### Claim at position 12

20-91. (canceled)