# US 2013/0157967 A1 · Use Of A Phospholipid-Containing Composition For The Removal Of Subcutaneous Fat Accumulations By Subcutaneous Lipolysis > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2013/0157967 A1 - Document ID: US20130157967A1 - Status: Published application - Kind: A1 - Application number: 13/642,916 - Filed: 2011-04-28 - Published: 2013-06-20 - Earliest claimed: 2010-04-29 - Assignees: Lichtblick SE - Inventors: Karl-Josef Gundermann; Dirk Brandl - Web page: https://patentgrep.com/patent/US20130157967A1 ## CPC - A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} - A61K 31/66: Phosphorus compounds - A61K 31/685: one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin - A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) - A61P 3/04: Anorexiants; Antiobesity agents - A61P 3/06: Antihyperlipidemics - A61P 17/00: Drugs for dermatological disorders - A61P 35/00: Antineoplastic agents - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - A61K 31/683: Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The invention described herein relates to the use of an aqueous composition containing at least one phospholipid. at least one glycyrrhizic acid or salts of glycyrrhizic acid for the manufacture of mediciments for the removal of subcutaneous fat accumulation. ## Claims ### Claim at position 1 1-16. (canceled) ### Claim 17 A method for the non-surgical removal of a subcutaneous fat accumulation from a patient, the method comprising: providing a composition comprising one or more phospholipids and one or more of glycyrrhizic acid and its salts, wherein the total content of the one or more phospholipids and the one or more of glycyrrhizic acid and its salts in the composition is 2-80 weight percent, and wherein the weight ratio between the one or more phospholipids and the one or more of glycyrrhizic acid and its salts is from 30:1 to 0.5:1; and administering an amount of the composition to the patient sufficient to non-surgically remove the subcutaneous fat accumulation from the patient. ### Claim 18 (depends on 17) The method according to claim 17 wherein the one or more phospholipids includes phosphatidyl choline. ### Claim 19 (depends on 18) The method according to claim 18 wherein the phosphatidyl choline is of animal or plant origin. ### Claim 20 (depends on 17) The method according to claim 17 wherein the composition includes one or more selected from the group consisting of glycyrrhizic acid, a potassium salt of glycyrrhizic acid, a sodium salt of glycyrrhizic acid, an ammonium salt of glycyrrhizic acid and a magnesium salt of glycyrrhizic acid. ### Claim 21 (depends on 17) The method according to claim 17 wherein the composition further comprises a sugar selected from the group consisting of glucose, maltose, mannitol, sorbitol, lactose and derivatives thereof. ### Claim 22 (depends on 17) The method according to claim 17 wherein 15 to 98 weight percent of the one or more phospholipids in the composition is phosphatidyl choline. ### Claim 23 (depends on 17) The method according to claim 17 wherein the composition is prepared for administration by dissolving a dry form of the one or more phospholipids and the one or more of glycyrrhizic acid and its salts in a suitable solvent. ### Claim 24 (depends on 23) The method according to claim 23 wherein the dry form of the one or more phospholipids and the one or more of glycyrrhizic acid and its salts is obtained as a lyophilisate by freeze-drying. ### Claim 25 (depends on 17) The method according to claim 17 wherein the composition is administered in the form of a solution. ### Claim 26 (depends on 17) The method according to claim 17 wherein the composition further comprises one or more physiologically suitable solvents. ### Claim 27 A method for the non-surgical treatment of a subcutaneous adipose tissue disorder with local disturbance of fat distribution in a patient, the method comprising: providing a composition comprising one or more phospholipids and one or more of glycyrrhizic acid and its salts, wherein the total content of the one or more phospholipids and the one or more of glycyrrhizic acid and its salts in the composition is 2-80 weight percent, and wherein the weight ratio between the one or more phospholipids and the one or more of glycyrrhizic acid and its salts is from 30:1 to 0.5:1; and administering an amount of the composition to the patient sufficient to non-surgically remove a subcutaneous fat accumulation from the patient. ### Claim 28 A method for the degradation and degeneration of an adipose tissue tumor in a patient, the method comprising: providing a composition comprising one or more phospholipids and one or more of glycyrrhizic acid and its salts, wherein the total content of the one or more phospholipids and the one or more of glycyrrhizic acid and its salts in the composition is 2-80 weight percent, and wherein the weight ratio between the one or more phospholipids and the one or more of glycyrrhizic acid and its salts is from 30:1 to 0.5:1; and administering an amount of the composition to the patient sufficient to non-surgically degrade and degenerate the adipose tissue tumor in the patient. ### Claim 29 (depends on 17) The method according to claim 17 wherein the composition is in a form selected from the group consisting of creams, ointments, gels, hydrogels, lotions, pastes, powders and solutions for percutaneous administration to the patient. ### Claim 30 (depends on 17) The method according to claim 17 wherein the subcutaneous fat accumulations removed are one more selected from the group consisting of lipedemas, lipomas, lipomatosis of the abdomen, dermatopanniculosis deformans, pseudogynecomastia, a Buffalo Hump in HIV patients, cellulitis, and nonspecific subcutaneous fat deposits. ### Claim 31 (depends on 17) The method according to claim 17 wherein the composition is administered to the patient by subcutaneous, intraperitoneal, intramuscular or intravenous injection. ### Claim 32 (depends on 17) The method according to claim 17 wherein the composition is administered to the patient by iontophoresis, electroporation or phonophoresis.