# US 2013/0157957 A1 · Moisturizing Composition Comprising an Aminopeptide Mixture

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2013/0157957 A1
- Document ID: US20130157957A1
- Status: Published application
- Kind: A1
- Application number: 13/688,949
- Filed: 2012-11-29
- Published: 2013-06-20
- Earliest claimed: 2011-12-19
- Assignees: Conopco, Inc., d/b/a UNILEVER
- Inventors: Eugene Pashkovski; Tamara Litvin; Alexander Lips
- Web page: https://patentgrep.com/patent/US20130157957A1

## CPC

- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/42: Amides
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/442: {substituted by amido group(s)}
- A61K 8/673: {Vitamin B group}
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/007: {Preparations for dry skin}
- A61K 2800/5922: At least two compounds being classified in the same subclass of A61K8/18
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention is directed to skin moisturizing compositions comprising an aminopeptide mixture. The composition replenishes the skins natural moisturization factor and delivers excellent sensory benefits. The composition is not unpleasantly viscous during and after application.

## Claims

### Claim 1

A skin composition comprising:
a) an aminopeptide mixture comprising:
i. a water soluble amino acid or functionalized amino acid;
ii. water soluble dipeptide having a molecular weight from about 150 to about 410;
iii. water soluble tripeptide having a molecular weight from about 225 to about 600 or water soluble vitamins comprising peptide bonds or both; and
b) cosmetically acceptable carrier
wherein amino acid and water soluble dipeptide together make up from 50 to 99% by weight of the total weight of the aminopeptide mixture.

### Claim 2 (depends on 1)

The skin composition according to claim 1 wherein the amino acid or functionalized amino acid has a partitioning coefficient log kp of −4.5 to 0 in n-octanol-water.

### Claim 3 (depends on 1)

The skin composition according to claim 1 wherein the amino acid or functionalized amino acid is selected from the group consisting of glutamine, aspargine, glycine, glutamic acid, threonine, lysine, alanine, serine, hydroxyproline, N-acetyl-L-tyrosine, N-acetyl-L-hydroxyproline, N-acetyl-L-cysteine, L-ornitine monochloride and a mixture thereof.

### Claim 4 (depends on 1)

The skin composition according to claim 1 wherein the dipeptide is glycyl-L-glytamine, glycyl-L-tyrosine, L-alanyl-L-glytamine, glycylglycine, lysyl lysine, glycyl alanine, glycyl lysine, glycyl hystidine or a mixture thereof.

### Claim 5 (depends on 1)

The skin composition according to claim 1 wherein the water soluble vitamin comprising peptide bond comprises D-L-panthenol and the water soluble vitamin derivative comprises calcium pantetheine-S-sulfonate.

### Claim 6 (depends on 1)

The skin composition according to claim 1 wherein the tripeptide is L-glytathione, S-methylglutathione, glycl-prolyl-glutaminc acid, lysyl-tyrosyl-lysine, lysyl-tyrosyl-lysine, glycyl-glycyl-histidine lysyl-lysyl-lysine or a mixture thereof.

### Claim 7 (depends on 1)

The skin composition according to claim 1 wherein total weight of amino acid and dipeptide in the aminopeptide mixture is from about 50 to 80%.

### Claim 8 (depends on 1)

The skin composition according to claim 1 wherein amino acid makes up from about 5 to about 50% by weight of the aminopeptide mixture.

### Claim 9 (depends on 1)

The skin composition according to claim 1 wherein the aminopeptide mixture has a glass transition temperature from about −75 to about 15° C.

### Claim 10 (depends on 1)

The skin composition according to claim 1 wherein the aminopeptide mixture has a glass transition temperature from about −48 to about 12° C.

### Claim 11 (depends on 1)

The skin composition according to claim 1 wherein the composition further comprises niacinamide.

### Claim 12 (depends on 1)

The skin composition according to claim 1 wherein the composition further comprises a cationic ammonium compound, substituted urea, glycerol or a mixture thereof.

### Claim 13 (depends on 1)

The skin composition according to claim 1 wherein the composition further comprises sunscreen, a resorcinol or a mixture thereof.

### Claim 14 (depends on 1)

The skin composition according to claim 1 wherein the composition is capable of replenishing skin natural moisturization factor.

### Claim 15 (depends on 1)

The skin composition according to claim 1 wherein the composition further comprises water, silicone and emulsifier.

### Claim 16 (depends on 1)

A method for moisturizing skin by replenishing natural moisturization factor of skin, the method comprising the step of topically applying to skin the composition of claim 1.