# US 2013/0156935 A1 · Methods for Coating Medical Devices > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2013/0156935 A1 - Document ID: US20130156935A1 - Status: Published application - Kind: A1 - Application number: 13/325,346 - Filed: 2011-12-14 - Published: 2013-06-20 - Earliest claimed: 2011-12-14 - Inventors: Rachit Ohri; Phillip Blaskovich; Lan Pham; David Giusti; Valentino Tramontano - Web page: https://patentgrep.com/patent/US20130156935A1 ## CPC - A61L 31/10: Macromolecular materials - A61L 15/22: containing macromolecular materials - A61L 17/145: {Coating} - A61L 27/34: Macromolecular materials - A61L 29/085: {Macromolecular materials} - A61L 2420/02: Methods for coating medical devices - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract Processes for coating medical devices are provided herein. The processes include heating a surface of the particles used to form the coating as the particles are being applied to the medical device. The resulting coating has improved adherence to the medical device, and does not require the use of solvents and/or water, obviating the need for any steps that otherwise might be required to remove these solvents and/or water. Sufficient adherence of the particles to the medical device may also occur without the need for heating the substrate used to form the medical device. ## Claims ### Claim 1 A method comprising: providing a medical device comprising a substrate; providing a source of polymeric particles; applying the polymeric particles to a surface of the substrate; and heating a surface of the particles as they travel from the source of the particles to the substrate, wherein the particles form a coating on at least a portion of the surface of the substrate upon contact therewith. ### Claim 2 (depends on 1) The method of claim 1, wherein the particles are applied to the substrate by a process selected from the group consisting of spray coating, air-assisted spraying, air-atomized spraying, ultrasonic spraying; electrospraying, airless spraying, high volume, low pressure spraying, powder coating, and combinations thereof. ### Claim 3 (depends on 1) The method of claim 1, wherein the surface of the particles is heated by a means selected from the group consisting of infrared, ultrasound, microwave, radiofrequency, visible light, and combinations thereof. ### Claim 4 (depends on 1) The method of claim 1, wherein the particles comprise microparticles possessing an average particle diameter of from about 5μ, to about 180μ. ### Claim 5 (depends on 1) The method of claim 1, wherein the particles comprise nanoparticles having an average particle diameter from about 50 nm to about 1000 nm. ### Claim 6 (depends on 1) The method of claim 1, wherein the surface of the particles is heated to a temperature above the glass transition temperature of the polymeric particles. ### Claim 7 (depends on 1) The method of claim 1, wherein the polymeric particles comprise glycolide, lactide, p-dioxanone, ε-caprolactone, trimethylene carbonate, orthoesters, phosphoesters, and combinations thereof. ### Claim 8 (depends on 1) The method of claim 1, wherein the polymeric particles comprise a copolymer of glycolide and lactide. ### Claim 9 (depends on 8) The method of claim 8, wherein glycolide is present in an amount from about 10% to about 50% by weight of the copolymer and lactide is present in an amount from about 50% to about 90% by weight of the copolymer. ### Claim 10 (depends on 8) The method of claim 8, wherein the surface of the polymeric particles is heated to a temperature of from about 35° C. to about 120° C. ### Claim 11 (depends on 1) The method of claim 1, wherein the medical device is selected from the group consisting of clips, fasteners, staples, sutures, pins, screws, prosthetic devices, wound dressings, bandages, drug delivery devices, anastomosis rings, surgical blades, contact lenses, intraocular lenses, surgical meshes, stents, stent coatings, grafts, catheters, stent/grafts, knotless wound closures, sealants, adhesives, contact lenses, intraocular lenses, anti-adhesion devices, anchors, tunnels, bone fillers, synthetic tendons, synthetic ligaments, tissue scaffolds, stapling devices, buttresses, lapbands, orthopedic hardware, pacers, pacemakers, fibers, textiles, and implants. ### Claim 12 (depends on 1) The method of claim 1, wherein the medical device comprises a mesh. ### Claim 13 (depends on 1) The method of claim 1, further comprising cooling the substrate as the particles are applied thereto. ### Claim 14 A method comprising: providing a medical device comprising a substrate; providing a source of polymeric particles; applying the polymeric particles to a surface of the substrate, the polymeric particles comprising at least one monomer selected from the group consisting of glycolide, lactide, p-dioxanone, ε-caprolactone, trimethylene carbonate, orthoesters, phosphoesters, and combinations thereof; and heating a surface of the particles to a temperature above the glass transition temperature of the polymeric particles as they travel from the source of the particles to the substrate, wherein the particles form a coating on at least a portion of the surface of the substrate upon contact therewith. ### Claim 15 (depends on 14) The method of claim 14, wherein the particles are applied to the substrate by a process selected from the group consisting of spray coating, air-assisted spraying, air-atomized spraying, ultrasonic spraying; electrospraying, airless spraying, high volume, low pressure spraying, powder coating, and combinations thereof. ### Claim 16 (depends on 14) The method of claim 14, wherein the surface of the particles is heated by a means selected from the group consisting of infrared, ultrasound, microwave, radiofrequency, visible light, and combinations thereof. ### Claim 17 (depends on 14) The method of claim 14, wherein the particles comprise microparticles possessing an average particle diameter of from about 5μ, to about 180μ. ### Claim 18 (depends on 14) The method of claim 14, wherein the particles comprise nanoparticles having an average particle diameter from about 50 nm to about 1000 nm. ### Claim 19 (depends on 14) The method of claim 14, wherein the polymeric particles comprise a copolymer of glycolide and lactide. ### Claim 20 (depends on 19) The method of claim 19, wherein glycolide is present in an amount from about 10% to about 50% by weight of the copolymer and lactide is present in an amount from about 50% to about 90% by weight of the copolymer. ### Claim 21 (depends on 19) The method of claim 19, wherein the surface of the polymeric particles is heated to a temperature of from about 35° C. to about 120° C. ### Claim 22 (depends on 14) The method of claim 14, wherein the medical device is selected from the group consisting of clips, fasteners, staples, sutures, pins, screws, prosthetic devices, wound dressings, bandages, drug delivery devices, anastomosis rings, surgical blades, contact lenses, intraocular lenses, surgical meshes, stents, stent coatings, grafts, catheters, stent/grafts, knotless wound closures, sealants, adhesives, contact lenses, intraocular lenses, anti-adhesion devices, anchors, tunnels, bone fillers, synthetic tendons, synthetic ligaments, tissue scaffolds, stapling devices, buttresses, lapbands, orthopedic hardware, pacers, pacemakers, fibers, textiles, and implants. ### Claim 23 (depends on 14) The method of claim 14, wherein the medical device comprises a mesh. ### Claim 24 (depends on 14) The method of claim 14, further comprising cooling the substrate as the particles are applied thereto. ### Claim 25 A system for applying a coating to a medical device comprising: at least one source of polymeric particles; at least one substrate; at least one spraying unit for applying the polymeric particles to the substrate; and at least one heating unit for heating a surface of the particles as they travel from the source of polymeric particles to the substrate.