# US 2013/0156870 A1 · Phytonutrient compositions and methods to protect against radical mediated cellular and dna damage

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- Number: US 2013/0156870 A1
- Document ID: US20130156870A1
- Status: Published application
- Kind: A1
- Application number: 13/715,794
- Filed: 2012-12-14
- Published: 2013-06-20
- Earliest claimed: 2011-12-15
- Assignees: Metaproteomics, LLC
- Inventors: Andrea Lyra HELLER; Brian CARROLL; Matthew L. TRIPP; Jeffrey S. BLAND
- Web page: https://patentgrep.com/patent/US20130156870A1

## CPC

- A61K 36/87: Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
- A61K 31/216: of acids having aromatic rings, e.g. benactizyne, clofibrate
- A61K 31/353: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K 31/366: having six-membered rings, e.g. delta-lactones
- A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin}
- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 36/31: Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K 36/42: Cucurbitaceae (Cucumber family)
- A61K 36/45: Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
- A61K 36/48: Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K 36/53: Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras
- A61K 36/736: Prunus, e.g. plum, cherry, peach, apricot or almond
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Phytonutrient based compositions and methods of using the same for preventing, reducing, or treating genetic damage induced by environmental toxins are disclosed.

## Claims

### Claim 1

A phytonutrient composition for preventing, reducing, or treating genetic damage induced by environmental agents, wherein said composition comprises therapeutically effective amounts of two or more compounds selected from the group consisting of Acacia nilotica extract, artichoke extract, blueberry extract, catechins, chlorogenic acid, cinnamon, ellagic acid, grape seed extract, hesperidin, Momodica extract, prune extract, rosemary extract, and watercress extract and said composition is in a dosage form suitable for oral administration.

### Claim 2 (depends on 1)

The composition according to claim 1, wherein said composition provides per dosage form:
a. from 0.5 mg to 10 mg of Acacia nilotica extract;
b. from 0.5 mg to 10 mg of artichoke extract;
c. from 1 mg to 25 mg of blueberry extract;
d. from 2.5 mg to 25 mg of catechins;
e. from 25 mg to 75 mg of chlorogenic acid;
f. from 0.5 mg to 10 mg of cinnamon;
g. from 10 mg to 100 mg of ellagic acid;
h. from 2.5 mg to 50 mg of grape seed extract;
i. from 15 mg to 120 mg of hesperidin;
j. from 0.5 mg to 10 mg of Momodica extract;
k. from 0.5 mg to 10 mg of prune extract;
l. from 0.5 mg to 10 mg of rosemary extract; and
m. from 0.5 mg to 10 mg of watercress extract.

### Claim 3

A method for preventing, reducing, or treating genetic damage induced by environmental agents, wherein said method comprises administering a composition comprising therapeutically effective amounts of two or more compounds selected from the group consisting of Acacia nilotica extract, artichoke extract, blueberry extract, catechins, chlorogenic acid, cinnamon, ellagic acid, grape seed extract, hesperidin, Momodica extract, prune extract, rosemary extract, and watercress extract and said composition is in a dosage form suitable for oral administration.

### Claim 4 (depends on 3)

The method according to claim 3, wherein said composition provides per dosage form:
a. from 0.5 mg to 10 mg of Acacia nilotica extract;
b. from 0.5 mg to 10 mg of artichoke extract;
c. from 1 mg to 25 mg of blueberry extract;
d. from 2.5 mg to 25 mg of catechins;
e. from 25 mg to 75 mg of chlorogenic acid;
f. from 0.5 mg to 10 mg of cinnamon;
g. from 10 mg to 100 mg of ellagic acid;
h. from 2.5 mg to 50 mg of grape seed extract;
i. from 15 mg to 120 mg of hesperidin;
j. from 0.5 mg to 10 mg of Momodica extract;
k. from 0.5 mg to 10 mg of prune extract;
l. from 0.5 mg to 10 mg of rosemary extract; and
m. from 0.5 mg to 10 mg of watercress extract.