# US 2013/0156864 A1 · Inorganic Cement for Biomedical uses, Preparation Method Thereof and Use of Same

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- Number: US 2013/0156864 A1
- Document ID: US20130156864A1
- Status: Published application
- Kind: A1
- Application number: 13/583,768
- Filed: 2011-03-11
- Published: 2013-06-20
- Earliest claimed: 2010-03-12
- Assignees: Universitat Politecnica De Catalunya
- Inventors: Maria Pau Ginebra Molins; Gemma Mestres Beà
- Web page: https://patentgrep.com/patent/US20130156864A1

## CPC

- A61K 33/42: Phosphorus; Compounds thereof
- A61K 6/54: Filling; Sealing
- A61K 6/853: Silicates
- A61K 6/864: Phosphate cements (apatite A61K6/838)
- A61K 33/08: Oxides; Hydroxides
- A61L 24/0015: {Medicaments; Biocides}
- A61L 24/02: containing inorganic materials
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2300/41: Anti-inflammatory agents, e.g. NSAIDs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

The present invention relates to a cement based on magnesium sodium phosphate with clinical applications in bone surgery and odontology. This cement has an intrinsic antimicrobial effect as its main property. It also has a fast setting time, along with a high short-term compressive strength. Another property inherent to these cements is their adhesive character. Use of the cement is indicated for bone and dental applications, as well as filling bone defects or sealing dental cavities. The cement is especially indicated in cases in which an antimicrobial effect and/or adhesive properties are necessary.

## Claims

### Claim 1

An inorganic cement for biomedical applications comprising a mixture of a solid phase formed by magnesium oxide (MgO) and a sodium phosphate, and a liquid phase formed by water or an aqueous solution.

### Claim 2 (depends on 1)

The cement according to claim 1, characterised in that the mixture reaction product is amorphous and increases the pH of the surrounding medium, giving it antimicrobial properties.

### Claim 3 (depends on 1)

The cement according to claim 1, wherein the sodium phosphate is sodium dihydrogen phosphate (NaH2PO4).

### Claim 4 (depends on 3)

The cement according to claim 3, characterised in that the magnesium oxide to sodium phosphate (MgO:NaH2PO4) molar ratio is greater than 1.

### Claim 5 (depends on 4)

The cement according to claim 4, wherein the magnesium oxide to sodium phosphate molar ratio is in the 1<MgO:NaH2PO4<6 range, the 3<MgO:NaH2PO4<5 range being preferred.

### Claim 6 (depends on 1)

The cement according to claim 1, characterised in that it comprises a retarder from among: sodium borate, boric acid, boric acid ester, sodium fluorosilicate, sodium polyphosphate and mixtures derived therefrom, at an amount of 0.05-10% by weight with respect to the powder phase of the cement, an amount between 2-6% by weight being more preferable.

### Claim 7 (depends on 1)

A method for preparing an inorganic cement for biomedical applications according to claim 1, characterised in that the MgO is calcined at a temperature greater than 1400° C. for 0.5-15 h for the purpose of reducing its reactivity.

### Claim 8 (depends on 7)

The method according to claim 7, wherein the setting time and the exothermic nature of the reaction are controlled by means of adding a retarder in the solid phase or in the liquid phase of the cement.

### Claim 9 (depends on 8)

The method according to claim 8, characterised by using sodium borate, boric acid, boric acid ester, sodium fluorosilicate, sodium polyphosphate and mixtures derived therefrom as a retarder, out of which sodium borate decahydrate or borax is preferred.

### Claim 10 (depends on 7)

The method according to claim 7, wherein the retarder is added at an amount of 0.05-10% by weight with respect to the powder phase of the cement, adding between 2-6% by weight being more preferable.

### Claim 11 (depends on 1, 2, 3, 4, 5, 6)

Use of a cement according to any one of claims 1 to 6 for bone and dental applications, especially in situations in which fighting a microbial infection is desired.

### Claim 12 (depends on 1, 2, 3, 4, 5, 6)

Use of a cement according to any of claims 1 to 6 for endodontic treatments such as directly and indirectly covering the pulp, sealing dentinal tubules, treating periapical inflammations or generally carrying out endodontic or apexification therapies.