# US 2013/0156746 A1 · Composition and method of manufacture > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2013/0156746 A1 - Document ID: US20130156746A1 - Status: Published application - Kind: A1 - Application number: 13/819,173 - Filed: 2011-08-25 - Published: 2013-06-20 - Earliest claimed: 2010-08-27 - Assignees: Persavita Ltd. - Inventors: Mahmood Piraee - Web page: https://patentgrep.com/patent/US20130156746A1 ## CPC - A61K 31/7024: Esters of saccharides - A23L 33/105: Plant extracts, their artificial duplicates or their derivatives - A23L 33/15: Vitamins - A23L 33/16: Inorganic salts, minerals or trace elements - A61K 31/047: having two or more hydroxy groups, e.g. sorbitol - A61K 31/05: Phenols {(cannabinoids A61K31/658)} - A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin - A61K 31/202: having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) - A61K 31/355: Tocopherols, e.g. vitamin E - A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof - A61K 31/59: Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems - A61K 33/30: Zinc; Compounds thereof - A61K 33/34: Copper; Compounds thereof - A61K 36/88: Liliopsida (monocotyledons) - A61P 27/02: Ophthalmic agents - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A dietary supplement composition includes a synergistic combination of saffron and resveratrol for providing anti-oxidant and gene modulation effects for preventing, ameliorating and/or reducing a rate of development and progression of age-related macular degeneration (AMD). Optionally, the combination is supplemented with one or more further ingredients: fish oil, Zinc, Copper, vitamin C, vitamin E, lutein, zeaxanthin. The combination is beneficially provided as a composition which is useful for reducing a risk of developing, and/or for reducing a rate of progression of age-related macular degeneration, and/or for preventing age-related sight loss, and other age-related diseases. ## Claims ### Claim 1 A composition for improving health, characterized in that said composition includes a combination of resveratrol and saffron. ### Claim 2 (depends on 1) The composition as claimed in claim 1, wherein said combination of resveratrol and saffron is implemented in a ratio of concentration of resveratrol: saffron powder being in a range of 1:1 to 100:1. ### Claim 3 (depends on 1) The composition as claimed in claim 1, wherein each dose of the composition includes in a range of 1 mg to 10000 mg resveratrol, and in a range of 0.2 mg to 2000 mg saffron powder. ### Claim 4 (depends on 3) The composition as claimed in claim 3, wherein each dose of the composition includes in a range of 5 mg to 5000 mg resveratrol, and in a range of 1 mg to 1000 mg saffron powder. ### Claim 5 (depends on 4) The composition as claimed in claim 4, wherein each dose of the composition includes in a range 50 mg to 700 mg resveratrol, and in a range of 2 mg to 300 mg saffron powder. ### Claim 6 (depends on 5) The composition as claimed in claim 5, wherein each dose is a daily dose of the composition which includes substantially 100 mg resveratrol and substantially 20 mg saffron powder. ### Claim 7 (depends on 1) The composition as claimed in claim 1, wherein the saffron has a crocin content of at least 0.1%, more preferably at least 1%, and most preferably at least 10%. ### Claim 8 (depends on 1) The composition as claimed in claim 1, wherein the resveratrol and/or the saffron, or components thereof, are synthesized using microbiological fermentation processes for manufacturing the composition. ### Claim 9 (depends on 1) The composition as claimed in claim 1, wherein the resveratrol and the saffron are arranged to be consumed temporally concurrently by users. ### Claim 10 (depends on 1) The composition as claimed in claim 1, wherein said composition additionally includes one or more of: lutein, zeaxanthin, vitamin C, vitamin E, vitamin D, fish oil comprising omega-3 fatty acids, Zinc, Copper, Copper oxide, botanical extracts, N-acetyl-cysteine, coenzyme Q10, L-carnitine and its derivatives, alpha-lipoic acid, and phytochemicals. ### Claim 11 (depends on 10) The composition as claimed in claim 10, wherein said vitamin C is provided in a form of ascorbic acid. ### Claim 12 (depends on 10) The composition as claimed in claim 10, wherein said vitamin E is provided in a form of di-alpha tocopheryl acetate. ### Claim 13 (depends on 10) The composition as claimed in claim 10, wherein said vitamin A is provided in a form of a retinly ester such as retinyl plamitate or retinyl acetate. ### Claim 14 (depends on 10) The composition as claimed in claim 10, wherein said Zinc is provided in a form of Zinc oxide, Zinc gluconate, or a combination thereof. ### Claim 15 (depends on 10) The composition as claimed in claim 10, wherein said Copper is provided in a form of Cupric oxide, Copper gluconate, Copper citrate, Copper bisglycinate, or a combination thereof. ### Claim 16 (depends on 10) The composition as claimed in claim 10, wherein said composition includes a quantity of Lutein and Zeaxanthin, supplied as an herbal extract, or as a purified compound. ### Claim 17 (depends on 16) The composition as claimed in claim 16, wherein said Lutein and Zeaxanthin are supplied as Marigold extract (Tagetes erecta) (FloraGlo™ or Optisharp™), or as a purified compound, ### Claim 18 (depends on 1) The composition as claimed in claim 1 arranged in liquid-form, powder-form, capsule-form and/or tablet-form. ### Claim 19 (depends on 1) A pack including a plurality of tablets and/or capsules including a composition as claimed in claim 1, wherein said pack includes said tablets and/or capsules disposed in manner together with graphical markings to assist users to consume a recommended dose of the composition over a period of duration extending over a plurality of days. ### Claim 20 A method of manufacturing a composition including a combination of resveratrol and saffron, wherein the composition is prepared in powder-form, in liquid-form, in capsular-form and/or in tablet form, wherein said method includes: (a) obtaining resveratrol and saffron and subjecting these to at least one of drying, crushing, mixing, blending operations; (b) preparing quantities of the composition in a form of liquid, powder, capsules and/or tablets; and (c) packaging the liquid, powder, capsules and/or tablets into packaging. ### Claim 21 (depends on 20) The method as claimed in claim 20, including adding edible carrier for providing bulk to the composition in step (a) of said method. ### Claim 22 (depends on 20) The method as claimed in claim 20, including providing said packaging with an arrangement for advising a suitable daily dose of the liquid, powder, capsules and/or tablets. ### Claim 23 (depends on 20, 21, 22) The method as claimed in claim 20, 21 or 22, wherein the composition is prepared to a dose including a range of 1 mg to 10000 mg resveratrol, a range of 0.2 mg to 2000 mg saffron powder. ### Claim 24 (depends on 1) A method of treating, ameliorating, preventing and/or decelerating development or progression of Age-related Macular Degeneration (AMD) and other age-related diseases, wherein the method includes administering to an individual a dietary nutritional composition comprising a composition as claimed in claim 1. ### Claim 25 A composition for improving health, wherein each dose of the composition includes in a range of 1 mg to 10000 mg resveratrol, and in a range of 0.2 mg to 2000 mg saffron powder.