# US 2013/0156739 A1 · Product for the upper gastric sphere

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- Number: US 2013/0156739 A1
- Document ID: US20130156739A1
- Status: Published application
- Kind: A1
- Application number: 13/814,887
- Filed: 2011-08-09
- Published: 2013-06-20
- Earliest claimed: 2010-08-13
- Assignees: Danone Argentina S.A.; Compagnie Gervais Danone
- Inventors: Ricardo Julian Weill; Céline Valentini
- Web page: https://patentgrep.com/patent/US20130156739A1

## CPC

- A61K 33/08: Oxides; Hydroxides
- A23C 9/00: Milk preparations; Milk powder or milk powder preparations (mixtures of whey with milk products or milk components A23C21/06; preservation of milk or milk preparations A23B11/10)
- A23C 9/1322: {Inorganic compounds; Minerals, including organic salts thereof, oligo-elements; Amino-acids, peptides, protein-hydrolysates or derivatives; Nucleic acids or derivatives; Yeast extract or autolysate; Vitamins; Antibiotics; Bacteriocins}
- A23C 9/133: Fruit or vegetables
- A23C 9/137: Thickening substances
- A23L 5/00: Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L 29/206: of vegetable origin
- A23L 29/272: {Gellan}
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/12: Fatty acids or derivatives thereof
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 9/00: Medicinal preparations characterised by special physical form {(nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations A61K49/18; preparations containing radioactive substances A61K51/12)}
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 47/02: Inorganic compounds
- A61K 47/24: containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 1/14: Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A23L 33/125: containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates (indigestible substances A23L33/21)
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23C: DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF (preservation thereof A23B11/00)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The invention concerns a product for the upper gastric sphere of humans. The product can address acidity in upper gastric sphere of humans. The product of the invention is typically to be administered orally, typically as food or food supplement. The product comprises a base product and several agents that provide benefits to the upper gastric sphere.

## Claims

### Claim 1

A product, comprising:
a) optionally a salivation agent,
b) optionally a mouth and/or throat cooling agent,
c) at least one gum,
d) a phospholipid product,
e) a base product comprising a mineral salt with a base anion, preferably a magnesium, sodium, calcium, or aluminum salt, and
f) a solid or liquid matrix.

### Claim 2 (depends on 1)

The product according to claim 1, wherein the product is a food product, a food supplement product or a pharmaceutical product.

### Claim 3 (depends on 1)

The product according to claim 1, wherein the salivation agent is selected from the group consisting of mono-, di-, or tricarboxylic acids or salts thereof, ascorbic acid and succinic acid or a salt thereof.

### Claim 4

(canceled)

### Claim 5 (depends on 1)

The product according to claim 1, wherein the cooling agent is a menthol compound, a cyclic carboxamide compound, or a mixture thereof.

### Claim 6

(canceled)

### Claim 7 (depends on 1)

The product according to claim 1, wherein the gum is selected from the group consisting of the following compounds: Gellan gums, xanthan gums, maltlodextrins, locust bean gums, carraghenan gums, alginates, carboxymethylcelluloses, methylcelluloses, and mixtures thereof.

### Claim 8 (depends on 1)

The product according to claim 1, wherein the phospholipid product is lecithinselected from the group consisting of soy lecithin, sunflower lecithin, rapeseed lecithin and fish oil lecithin.

### Claim 9 (depends on 1)

The product according to claim 1, wherein the base product is a magnesium product, comprising at least a magnesium salt with a base anion selected from the group consisting of carbonate, hydroxide, oxide, trisilicate, phosphate, organic acid anion, such as lactate, and mixtures thereof.

### Claim 10

(canceled)

### Claim 11 (depends on 1)

The product according to claim 1, wherein the base product is a magnesium product comprising: metallic magnesium or a magnesium salt selected from the group consisting of magnesium carbonate, magnesium hydroxide, magnesium oxide, magnesium trisilicate, magnesium phosphate, magnesium salts of organic acids, such as magnesium lactate, and mixtures thereof.

### Claim 12

(canceled)

### Claim 13 (depends on 11)

The product according to claim 11, wherein the magnesium product comprises metallic magnesium, MgO, Mg Lactate, and glycine.

### Claim 14 (depends on 1)

The product according to claim 1, wherein the matrix is a liquid comprising animal milk, vegetal milk or fruit juice.

### Claim 15 (depends on 1)

The product according to claim 1, wherein the matrix comprises at least 1% by weight of proteins.

### Claim 16 (depends on 1)

The product according to claim 1, wherein the product has a water content ranging from 50 to 99% by weight.

### Claim 17 (depends on 14)

The product according to claim 14, wherein the matrix comprises microorganisms selected from the group consisting of lactic acid bacteria and probiotics.

### Claim 18

(canceled)

### Claim 19 (depends on 14)

The product according to claim 14, that is a yogurt or a fermented milk product.

### Claim 20 (depends on 1)

The product according to claim 1, that is in a powder form, a tablet form, a capsule form, or a bar form.

### Claim 21 (depends on 1)

The product according to claim 1 comprising:
a) optionally from 0.0001% to 0.1% by weight of the salivation agent,
b) optionally from 0.0001% to 0.1% by weight of the mouth and/or throat cooling agent,
c) from 0.1 to 10% by weight of the gum
d) from 0.1 to 10% by weight of phospholipid product,
e) from 0.1 to 10% by weight of the base product, and
f) from 0.1 to 99% by weight of matrix.

### Claim 22 (depends on 1)

The product according to claim 1 having a viscosity ranging from 90 to 360 mPa·s at 10 s″1 at 37° C., and/or 200 to 1000 mPa·s at 10 s″1 at 10° C.

### Claim 23 (depends on 1)

The product according to claim 1, having a pH ranging from 4 to 8.5.

### Claim 24 (depends on 1)

A process of making the product according to claim 1, comprising the step of mixing at least one gum, a phospholipid product, a base product comprising a mineral salt with a base anion, preferably a magnesium, sodium, calcium, or aluminum salt, and a solid or liquid matrix optionally in combination with a salivation agent and/or a mouth and/or throat cooling agent or components thereof.

### Claim 25 (depends on 1)

A method of providing prevention of or relief from and/or treatment of stomach or esophagus pain in a subject in need thereof comprising administering the product of claim 1 to the subject.

### Claim 26 (depends on 1)

A method for protecting the esophagus of a subject from acid reflux, comprising administering the product of claim 1 to the subject in an amount effective to increase the pH of the gastric liquid and/or providing some covering of the mucosa of the esophagus.

### Claim 27 (depends on 26)

The method according to claim 26, wherein the pH of stomach juice after administration of the product is increased, compared to the pH of stomach juice before or without administration of product.

### Claim 28 (depends on 27)

The method according to claim 27, where the pH is increased of a mean value of less than 2.4 and/or the pH of stomach juice after administration of the composition is less than 5.

### Claim 29 (depends on 26)

The method according claim 26, for daily use, during a period of more than 15 days.