# US 2013/0153474 A1 · Apparatus for extracorporeal blood treatment, comprising a measuring device for determining the luminescence of the spent dialysate

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- Number: US 2013/0153474 A1
- Document ID: US20130153474A1
- Status: Published application
- Kind: A1
- Application number: 13/702,846
- Filed: 2011-06-10
- Published: 2013-06-20
- Earliest claimed: 2010-06-11
- Assignees: B. Braun Avitum AG
- Inventors: Aleksandr Frorip; Christoph Nacke; Stefan Moll; Alex Castellarnau; Joern Meibaum
- Web page: https://patentgrep.com/patent/US20130153474A1

## CPC

- A61M 1/1692: {Detection of blood traces in dialysate}
- A61M 1/16: with membranes
- A61M 1/1609: {after use, i.e. downstream of dialyser}
- A61M 2205/3306: Optical measuring means
- A61M 2205/50: with microprocessors or computers
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

The invention relates to an apparatus for extracorporeal blood treatment having a dialyzer which is divided into a first and a second chamber 29, 30 by means of a semipermeable membrane wherein the first chamber 29 is arranged in a dialysate path and the second chamber 30 can be connected to a patient's blood circulation by means of a blood supply line 32 and a blood discharge line 31, an inlet 20 for fresh dialysate, an outlet 36 for spent dialysate, a measuring device 37, wherein the measuring device 37 has at least one radiation source 1 for substantially monochromatic electromagnetic radiation. Thereby the measuring device 37 for determination of a luminescence of the spent dialysate flowing through the outlet 36 has at least one detector system (5) for detecting the intensity of the electromagnetic radiation generated by luminescence.

## Claims

### Claim at position 1

1-15. (canceled)

### Claim 16

An apparatus for extracorporeal blood treatment comprising
a dialyzer which is divided into a first and a second chamber by means of a semipermeable membrane, wherein the first chamber is arranged in a dialysate path and second chamber is connected to a patient's blood circulation by means of a blood supply line and a blood discharge line,
an inlet for fresh dialysate,
an outlet for spent dialysate,
a measuring device that is arranged in the outlet, wherein the measuring device includes at least one radiation source for substantially monochromatic electromagnetic radiation, characterized in that
the measuring device for determination of a luminescence of the spent dialysate flowing through the outlet includes at least one detector system for detection of the intensity of the electromagnetic radiation generated by luminescence.

### Claim 17 (depends on 16)

The apparatus according to claim 16, wherein that the radiation source for emission of electromagnetic radiation is designed in the range of 1 nm to 750 nm, particularly in the range of ultra-violet radiation of 1 nm to 380 nm.

### Claim 18 (depends on 16)

The apparatus according to claim 16, wherein that the detector system for detection electromagnetic radiation is designed in the range of 1 nm to 750 nm.

### Claim 19 (depends on 16)

The apparatus according to claim 16, wherein that the at least one radiation source for the substantially monochromatic electromagnetic radiation has a polychromatic radiation source and a monochromator, particularly an optical filter permeable for only a specific wave length or a bandpass filter with one or several pass ranges.

### Claim 20 (depends on 16)

The apparatus according to claim 16, wherein that the at least one detector system for detection of the intensity of the electromagnetic radiation generated by luminescence has an optical filter permeable for only a specific wave length or a bandpass filter with one or several pass ranges.

### Claim 21 (depends on 16)

The apparatus according to claim 16, wherein that the detector system is designed as a fluorescence detector.

### Claim 22 (depends on 16)

The apparatus according to claim 16, wherein that the detector system with its optical axis is arranged substantially orthogonal to the optical axis of the radiation source.

### Claim 23 (depends on 16)

The apparatus according to claim 16, wherein that the measuring device has a reference detector.

### Claim 24 (depends on 16)

The apparatus according to claim 16, wherein that the measuring device has a light beam divider, which is arranged between radiation source and outlet.

### Claim 25 (depends on 16)

The apparatus according to claim 16, wherein that the measuring device has an absorption detector which is preferably arranged in the optical axis of the radiation source, wherein the outlet is arranged between absorption detector and radiation source in their optical axis.

### Claim 26 (depends on 16)

The apparatus according to claim 16, wherein that the radiation source is designed for pulsed or continuous emission of electromagnetic radiation.

### Claim 27 (depends on 16)

The apparatus according to claim 16, wherein that it further has a microprocessor unit, a storage unit as well as an output unit.

### Claim 28 (depends on 27)

The apparatus according to claim 27, wherein that the storage unit is designed for storage of reference data.

### Claim 29 (depends on 28)

The apparatus according to claim 28, wherein that the microprocessor unit is designed for the modification of different apparatus parameters such as dialysate flow, blood flow, dialyzer or the like, by means of a comparison of the measured values with the reference data.

### Claim 30 (depends on 27)

The apparatus according to one of claim 27, wherein that the measurement results provided by the detector system are displayable on the output unit, e.g. a printer or a monitor.

### Claim 31 (depends on 28)

The apparatus according to one of claim 28, wherein that the measurement results provided by the detector system are displayable on the output unit, e.g. a printer or a monitor.

### Claim 32 (depends on 29)

The apparatus according to one of claim 29, wherein that the measurement results provided by the detector system are displayable on the output unit, e.g. a printer or a monitor.
