Haemophilus Influenzae Type IV PILI
AssigneeNationwide Children's Hospital, Inc.
InventorsLauren O. Bakaletz, Robert S. Munson, JR.
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Abstract
The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.
Claims20
An isolated polynucleotide comprising a nucleotide sequence encoding an amino acid sequence of any one of:
- PilA polypeptide SEQ ID NO:
- 2, PilB polypeptide SEQ ID NO:
- 4, PilC polypeptide SEQ ID NO:
- 6, PilD polypeptide SEQ ID NO:
- 8, ComA polypeptide SEQ ID NO:
- 10, ComB polypeptide SEQ ID NO:
- 12, ComC polypeptide SEQ ID NO:
- 14, ComD polypeptide SEQ ID NO:
- 16, ComE polypeptide SEQ ID NO:
- 18, ComF polypeptide SEQ ID NO:
- 20, PilF polypeptide SEQ ID NO:
- 22, PilA polypeptide SEQ ID NO:
- 26, PilA polypeptide SEQ ID NO:
- 26, PilA polypeptide SEQ ID NO:
- 28, PilA polypeptide SEQ ID NO:
- 30, PilA polypeptide SEQ ID NO:
- 32, PilA polypeptide SEQ ID NO:
- 34, PilA polypeptide SEQ ID NO:
- 36, PilA polypeptide SEQ ID NO:
- 38, PilA polypeptide SEQ ID NO:
- 40, PilA polypeptide SEQ ID NO:
- 42, or pilA polypeptide SEQ ID NO:
- 44.
An isolated polynucleotide comprising a nucleotide sequence of any one of:
- pilA SEQ ID NO:
- 1, pilB SEQ ID NO:
- 3, pilC SEQ ID NO:
- 5, pilD SEQ ID NO:
- 7, comA SEQ ID NO:
- 9, comB SEQ ID NO:
- 11, comC SEQ ID NO:
- 13, comD SEQ ID NO:
- 15, comE SEQ ID NO:
- 17, comF SEQ ID NO:
- 19, pilF SEQ ID NO:
- 21, pilA SEQ ID No:
- 25, pilA SEQ ID No:
- 27, pilA SEQ ID No:
- 29, pilA SEQ ID No:
- 31, pilA SEQ ID No:
- 33, pilA SEQ ID No:
- 35, pilA SEQ ID No:
- 37, pilA SEQ ID No:
- 39, pilA SEQ ID No:
- 41 or pilA SEQ ID No:
- 43.
An isolated polypeptide comprising an amino acid sequence of any one of PilA polypeptide SEQ ID NO:
- 2, PilB polypeptide SEQ ID NO:
- 4, PilC polypeptide SEQ ID NO:
- 6, PilD polypeptide SEQ ID NO:
- 8, ComA polypeptide SEQ ID NO:
- 10, ComB polypeptide SEQ ID NO:
- 12, ComC polypeptide SEQ ID NO:
- 14, ComD polypeptide SEQ ID NO:
- 16, ComE polypeptide SEQ ID NO:
- 18, ComF polypeptide SEQ ID NO:
- 20, PilF polypeptide SEQ ID NO:
- 22, PilA polypeptide SEQ ID NO:
- 26, PilA polypeptide SEQ ID NO:
- 26, PilA polypeptide SEQ ID NO:
- 28, PilA polypeptide SEQ ID NO:
- 30, PilA polypeptide SEQ ID NO:
- 32, PilA polypeptide SEQ ID NO:
- 34, PilA polypeptide SEQ ID NO:
- 36, PilA polypeptide SEQ ID NO:
- 38, PilA polypeptide SEQ ID NO:
- 40, PilA polypeptide SEQ ID NO:
- 42, or pilA polypeptide SEQ ID NO:
- 44, or a peptide fragment thereof.
A composition comprising an antibody of claim 8 and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.