Method to detect and treat infectious or inflammatory diarrhea based on reg1
AssigneeUniversity of Virginia Patent Foundation
InventorsWilliam A. Petri, JR., Kristine Peterson
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Abstract
The present invention relates to methods for the diagnosis, treatment and prevention of infectious and/or inflammatory diarrhea.
Claims22
A method for diagnosing infectious or inflammatory diarrhea comprising detecting the presence of Reg1 protein or mRNA in a fecal sample or intestinal biopsy from a subject, wherein the presence of Reg1 protein or mRNA in the fecal sample or intestinal biopsy indicates that the subject has infectious and/or inflammatory diarrhea.
A method for diagnosing infectious or inflammatory diarrhea comprising obtaining a fecal sample from a subject, determining the sample contains Reg1 protein, and diagnosing the subject with infectious and/or inflammatory diarrhea.
A method for diagnosing infectious or inflammatory diarrhea comprising obtaining an intestinal biopsy from a subject, determining the biopsy contains Reg1 mRNA or protein, and diagnosing the subject with infectious and/or inflammatory diarrhea.
A method for determining if treatment of infectious or inflammatory diarrhea is efficacious comprising detecting the presence of Reg1 protein or mRNA in a fecal sample or intestinal biopsy from a subject, wherein the presence of a reduced amount Reg1 protein or mRNA in the fecal sample or intestinal biopsy as compared to a sample from the subject taken earlier indicates that the treatment is effective.
A method to treat infectious and/or inflammatory diarrhea comprising administering to a subject in need thereof an effective amount of at least one Reg1 protein, or an active homolog, variant or fragment thereof.
Prophylaxis treatment of infectious and/or inflammatory diarrhea comprising administering to a subject an effective amount of at least one Reg1 protein, or an active homolog, variant or fragment thereof.
Dependencies are inferred from the claim text.