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US 2013/0115675 A1Published application
Dehalogenases, Nucleic Acids Encoding Them and Methods for Making and Using Them
AssigneeVerenium Corporation
InventorsJay M. Short, Toby Richardson, Dan E. Robertson, Kevin A. Gray
Life of this patent
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Abstract
The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature.
Claims2
An isolated, synthetic or recombinant nucleic acid comprising
- (a) a nucleic acid sequence having at least 90% sequence identity to SEQ ID NOS:
- 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 43, 45, and 47, wherein the nucleic acid encodes at least one polypeptide having a dehalogenase activity or encodes at least one polypeptide capable of generating an antibody response by administering the polypeptide to an animal;
- or
- (b) a sequence complementary to (a).
1 more element
An isolated, synthetic or recombinant polypeptide having a dehalogenase activity comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NOS:
- 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 43, 45, and 47.
Dependencies are inferred from the claim text.