Micheliolide derivatives, medicinal composition, producing method and usage thereof

A compound of the formula (I):

• Wherein:
• R1 is any of H, —C(O)R4 and —C(O)R5R6, wherein, R4, R5 and R6 are any of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, alkyaryl, arylakyl, arylalkenyl, arylalkynyl and heterocyclic respectively;
• R3 is hydrogen, R2 is alkyl with C1-8, containing substituent or R2═R3 is double bond;
• X is any of O and R10N, wherein, R10 is any of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, alkyaryl, arylakyl, arylalkenyl, arylalkynyl and heterocyclic;
• Y is any of single bond, O, R11N and R12R13C, wherein, R11 is any of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, alkyaryl, arylakyl, arylalkenyl, arylalkynyl or heterocyclic;
• R12 and R13 are any of hydrogen, fluorine, chlorine, bromine, iodine, alkyl, cycloalkyl, alkyl substituted by hydroxyl, alkenyl, alkynyl, aryl, heterocyclic, arylakyl, arylalkenyl, arylalkynyl, cyanomethyl, alkoxy or aryloxyalkyl respectively;
• Herein, R1 being H, Y being single bond, and R2═R3 being double bond do not exist at the same time.