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AssigneePhycal, Inc.
InventorsF.C. Thomas Allnutt, Bradley Lynn Postier, Richard T. Sayre, Daniel A. Coury, Anil Kumar, Andrew Swanson, Mark Scott Abad, Zoee Gokhale Perrine
Estimating the term…
Biosecure algae and methods for preparing biosecure algae that have a substantially decreased capability to survive in a natural environment are described. The methods include transforming a genetically modified alga to include an essential gene that is operably linked to a promoter system that is active only in the presence of an inducer compound, transforming the genetically modified alga to include a lethal gene that is operably linked with a promoter system that is inactive only in the presence of a repressor compound. The biosecure algae are only able to survive in an artificial algae culture that includes factors or conditions not found in a natural environment.
A biosecure alga consisting of a genetically modified alga comprising an essential gene that is operably linked to a promoter system that is active only in the presence of an inducer compound.
A biosecure alga consisting of a genetically modified alga comprising a lethal gene that is operably linked with a promoter system that is inactive only in the presence of a repressor compound.
A biosecure alga consisting of a genetically modified alga comprising a constitutively expressed toxin gene and a corresponding antitoxin gene operably linked to a promoter system that is active only in the presence of an inducer compound.
A method of culturing of a genetically modified alga in a biosecure manner, comprising culturing a genetically modified alga including a disrupted UV repair gene in an artificial environment providing low UV exposure.
Dependencies are inferred from the claim text.