Hypodermic needle assembly having a transition hub for enhancing fluid dynamics and microsphere injectability

A method of delivering a microsphere drug to a patient utilizing a hypodermic needle assembly having an injection needle defining a passageway through the injection needle, an injection device defining a passageway through the injection device, and a transition hub defining a cavity in the transition hub including a transition portion having a first end and a second end between the first end and an inlet of the passageway of the injection needle and having a gradually decreasing diameter from the first end to the second end, the diameter at the second end being substantially the same as a diameter of the inlet of the passageway of the injection needle, the transition hub being coupled between the injection needle and the injection device such that the first end of the transition portion is in fluidic communication with the passageway of the injection device and the second end of the transition portion is in fluidic communication with the passageway of the injection needle, the method comprising:

• inserting an outlet end of the injection needle into the patient;
• and
• ejecting the microsphere drug through an outlet of the passageway of the injection device such that the microsphere drug passes through the cavity of the transition hub and subsequently through the passageway of the injection needle.