System, method and article for normalization and enhancement of tissue images

A system for use in tissue analysis, the system comprising:

• at least one processor;
• and
• at least one nontransitory storage medium that stores processor executable instructions which when executed cause the at least one processor to:
• compare an appearance of at least one shape of at least a first fiducial marker in a first digital image of a portion of a tissue to at least one defined actual shape of the fiducial marker;
• compare an appearance of each of a plurality of sections of the fiducial marker in the first digital image to respective ones of defined sections of the fiducial marker including a number of tissue phantoms each having a respective spectral characteristic that matches a respective spectral characteristic of tissue of a type represented in the first digital image;
• and
• at least one of correlate, normalize, or correct at least the first digital image, based at least in part on the comparisons.

A system to image bodily tissues, the system comprising:

• a physical fiducial marker selectively positionable at least proximate a region of interest on a portion of a bodily tissue to be imaged, the physical fiducial marker including a substrate having a defined profile and bearing a plurality of sections having respective wavelength selective absorption, reflectance or florescence characteristic, at least a first number of the sections form a color chart of a plurality of different colors and at least a second number of the sections are optical phantoms that match respective ones of a number of spectral characteristics of living tissue;
• at least one light source operable to project a virtual fiducial marker at least proximate the region of interest on the portion of the bodily tissue to be imaged, the virtual fiducial marker having a defined profile and a plurality of defined shapes;
• and
• an image capture device having a field of view and configured to capture digital images of bodily tissue including the region of interest, the physical fiducial marker and the virtual fiducial marker all encompassed by the field of view of the image capture device.

A system for use in tissue analysis, the system comprising:

• at least one processor;
• and
• at least one nontransitory storage medium that stores processor executable instructions which when executed cause the at least one processor to:
• assess a change in at least one of a level of hydration, a level of blood flow, a total number of wrinkles, a size of at least one wrinkle, a total number of blemishes, or a size of at least one blemish between a first digital image of a region of interest of a bodily tissue and at least one subsequent digital image of the region of interest of the bodily tissue, where the first digital image represents the region of interest prior to a first application of a cosmetic, a moisturizer, a therapeutic or a therapeutic treatment and the at least one subsequent digital mage represents the region of interest after the first application of the cosmetic, the moisturizer, the therapeutic or the therapeutic treatment;
• and
• report the assessed difference in a visual form.