Modafinil Compositions
AssigneeCephalon, Inc.
InventorsMagali Bourghol Hickey, Matthew Peterson, Orn Almarsson, Mark Oliveira
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Abstract
Polymorphs and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and discussed. In addition, said forms are described as useful for the treatment of many conditions including, but not limited to, narcolepsy.
Claims20
A crystalline form comprising R-(−)-modafinil and S-(+)-modafinil in a ratio of about 2:1 characterized by a powder X-ray diffraction pattern comprising one or more of the following peaks:
- 8.95±about 0.1 degrees 2-theta;
- 10.17±about 0.1 degrees 2-theta;
- 11.87±about 0.1 degrees 2-theta;
- 14.17±about 0.1 degrees 2-theta;
- 15.11 ±about 0.1 degrees 2-theta;
- 17.39±about 0.1 degrees 2-theta;
- 18.31±about 0.1 degrees 2-theta;
- 20.39±about 0.1 degrees 2-theta;
- 21.09±about 0.1 degrees 2-theta;
- 24.21±about 0.1 degrees 2-theta;
- 26.45±about 0.1 degrees 2-theta.
A crystalline form comprising R-(−)-modafinil and S-(+)-modafinil in a ratio of about 2:1 characterized by a powder X-ray diffraction pattern comprising one or more of the following peaks:
- 8.97±about 0.1 degrees 2-theta;
- 10.15±about 0.1 degrees 2-theta;
- 12.87±about 0.1 degrees 2-theta;
- 14.15±about 0.1 degrees 2-theta;
- 15.13±about 0.1 degrees 2-theta;
- 15.77±about 0.1 degrees 2-theta;
- 18.19±about 0.1 degrees 2-theta;
- 20.39±about 0.1 degrees 2-theta.
Dependencies are inferred from the claim text.