Nitrile hydration catalyzed by recyclable ruthenium complexes
AssigneeBoard of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada
InventorsBrian J. Frost, Wei-Chih Lee
Life of this patent
Estimating the term…
Abstract
A method for hydrating a nitrile derivative to generate an amide derivative is provided. The method includes mixing the nitrile derivative with a ruthenium catalyst complex in an aqueous solution to form a mixture, and reacting the nitrile derivative with water in the aqueous solution and in the presence of the ruthenium catalyst complex to form a reacted mixture comprising the amide derivative. The ruthenium catalyst complex is represented by the following structural formula: RuX2(L)n, wherein X is an anionic ligand, L is a bifunctional phosphine ligand, and n is 3 or 4.
Claims20
A method for hydrating a nitrile derivative to generate an amide derivative comprising:
- mixing the nitrile derivative with a ruthenium catalyst complex in an aqueous solution to form a mixture, the ruthenium catalyst complex represented by the following structural formula:
- RuX2(L)n,
- wherein X is an anionic ligand, L is a bifunctional phosphine ligand, and n is either 3 or 4;
- and
- reacting the nitrile derivative with water in the aqueous solution and in the presence of the ruthenium catalyst complex to form a reacted mixture comprising the amide derivative.
Dependencies are inferred from the claim text.