Novel rhodamine dyes and conjugates
AssigneePharmacophotonics, Inc.
InventorsUlf Bremberg, Erik Ringberg, Wei Berts, Anthony De Belder, James S. Strickland
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Abstract
The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.
Claims23
(canceled)
The composition of claim 11 wherein the novel rhodamine dye contains a julolidine structure element.
The composition of claim 11 wherein the functional group is selected from the group consisting of amines, alcohols, isocyanates, isothiocyanates, thiols, and carboxylic acids.
The composition of claim 11 wherein the other molecule is a macromolecule.
The composition of claim 11 wherein the salt is selected from the group consisting of trifluoroacetate, chloride, hydrochloride, hydrobromide, hydroiodide, nitrate, sulfate, bisulfate, phosphate, acid phosphate, isonicotinate, acetate, lactate, salicylate, citrate, tartrate, pantothenate, bitartrate, ascorbate, succinate, maleate, gentisinate, fumarate, gluconate, glucuronate, saccharate, fortmate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzensulfonate and p-toluenesulfonate.
The composition of claim 11 wherein the salt is trifluoroacetate or chloride.
The composition of claim 11 wherein the salt is a pharmaceutically acceptable salt.
A composition comprising a novel rhodamine dye or a salt thereof with the general structure of
- wherein R1, R2, R3, R4 and R5 can be H or any group, and wherein only one of R1, R2, R3, R4 or R5 contains a single functional group, and wherein the rhodamine dye is capable of conjugating with another molecule via the functional group to form a single isomeric conjugation product.
12-17. (canceled)
The composition of claim 120 wherein the spacer is selected from the group consisting of hydrogen, alkyl, aryl, amide, alkyl sulfonamide, alkyl ether and alkyl amide.
The composition of claim 120 wherein R1 and R2 are connected to form a cyclic structure.
22-26. (canceled)
The composition of claim 120 undergoing a re-arrangement to form an isomer having the structure of
31-119. (canceled)
Dependencies are inferred from the claim text.