Polymer conjugates of glp-1
AssigneeNektar Therapeutics
InventorsMary J. BOSSARD, Zhihao Fang, Tacey X. Viegas, Stewart A. Thompson, Mei-chang Kuo
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Abstract
Conjugates of a GLP-1 moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-1 polymer conjugate may include a GLP-1 moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-1 polymer conjugate may include a GLP-1 moiety covalently attached to a water-soluble polymer, wherein the GLP-1 moiety possesses an N-methyl substituent.
Claims9
A GLP-1 polymer conjugate comprising a GLP-1 moiety releasably attached at an amine to a water-soluble polymer, wherein the conjugate is formed by contacting the GLP-1 moiety with a polymeric reagent of the following structure:
- where:
- POLY1 is a first water-soluble polymer;
- POLY2 is a second water-soluble polymer;
- X1 is a first spacer moiety;
- X2 is a second spacer moiety;
- Hα is an ionizable hydrogen atom;
- R1 is H or an organic radical;
- R2 is H or an organic radical;
- and
- (FG) is a functional group capable of reacting with an amino group of the GLP-1 moiety.
Dependencies are inferred from the claim text.