Quinoline derivatives and uses of the same
AssigneeNational Taipei University of Technology
InventorsKuo-Yuan HWA, Yu-May LEE, Yeh-Long CHEN, Cherng-Chyi TZENG, Hsin-Yuan CHO
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Abstract
Provided is a quinoline derivative of Chemical Formula (I): wherein, R1 is a substituted or unsubstituted phenyl group, R2 is a halogen, and R3 is a substituted or unsubstituted phenyl group, and one of the carbon atoms in the phenyl ring of the phenyl group is optionally substituted by a nitrogen atom (N). The quinoline derivative can efficiently inhibit cancer cell proliferation and can be used for treating cancer, especially for treating cancers related to the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway and/or the mitogen-activated protein kinase (MAPK) pathway.
Claims17
A quinoline derivative represented by Chemical Formula (I):
- wherein,
- R1 is a substituted or unsubstituted phenyl group;
- R2 is a halogen;
- and
- R3 is a substituted or unsubstituted phenyl group, and one of the carbon atoms in the phenyl ring of the phenyl group is optionally substituted by a nitrogen atom (N).
Dependencies are inferred from the claim text.