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US 2013/0096149 A1Published application
Heteroaryl compounds and compositions as protein kinase inhibitors
AssigneeNovartis AG
InventorsAnn Marie Madera, Daniel Poon, Aaron Smith
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds of Formula I: wherein R1, R2, R3, and X are as defined herein. The compounds of Formula (I) and pharmaceutical compositions thereof are useful for the treatment of cancer, and B-Raf-associated diseases.
Claims21
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- X represents O or S;
- R1 is selected from C1-6-alkyl, C3-8 branched alkyl, C3-8 cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, and optionally substituted aryl;
- R2 is heteroaryl substituted with R11;
- R3 is phenyl substituted with R12, R13, and R15;
- R11 is selected from H, and optionally substituted amino;
- R12 is halogen and H;
- R13 is NHSO2alkyl;
- and
- R15 is selected from halogen, H, and C1-6 alkyl.
7 more elements
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- X represents O or S;
- R1 is selected from C3-6 branched alkyl, C3-6 cycloalkyl, and optionally substituted phenyl;
- R2 is heteroaryl substituted with R11;
- R3 is phenyl substituted with R12, R13, and R15;
- R11 is selected from H, amino, and NH—CH2—CH(CH3)NH—C(O)—OCH3;
- R12 is halogen;
- R13 is NHSO2C1-6 alkyl;
- and
- R15 is selected from halogen, H, and C1-6 alkyl.
7 more elements
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- X represents O or S;
- R1 is selected from C3-6 branched alkyl, C3-6 cycloalkyl, and optionally substituted phenyl;
- R2 is heteroaryl substituted with R11;
- R3 is phenyl substituted with R12, R13, and R15;
- R11 is selected from H, NH(CH2)1-2—CN, and amino;
- R12 is halogen;
- R13 is NHSO2 C1-6 alkyl;
- and
- R15 is selected from halogen, H, and C1-6 alkyl.
7 more elements
(canceled)
(canceled)
-14. (canceled)
-36. (canceled)
Dependencies are inferred from the claim text.