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US 2013/0096133 A1Published application
Procaspase-activating compounds and compositions
AssigneeThe Board of Trustees of the University of lllinois
InventorPaul J. HERGENROTHER
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Abstract
The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.
Claims15
A compound that directly activates procaspase-3 upon contacting procaspase-3, wherein the compound is a novel compound of Formula I:
- wherein
- R1 is an optionally substituted phenyl or (aryl)methylene, or (aryl)methine wherein the methine carbon is optionally substituted with phenyl;
- n is 1, 2, 3, or 4;
- and
- each R2 is independently H, alkyl, alkoxy, hydroxy, halo, amino, alkylamino, dialkylamino, trifluoromethoxy, benzyl, benzyloxy, nitro, 2-propenyl, acetylene, N-alkyl-triazole, or N-benzyl-triazole;
- or two R2 groups form an ortho-fused benzo group;
- or a pharmaceutically acceptable salt or solvate thereof.
4 more elements
The compound:
Dependencies are inferred from the claim text.