Substituted aminopropionic derivatives as neprilysin inhibitors

A compound of Formula I′:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is H, C1-7alkyl, hydroxy, C1-7alkoxy, halogen, —SH, —S—C1-7alkyl or NRaRb;
• R2 for each occurrence, is independently C1-7alkyl, halo, NO2, CN, C1-7alkanoylamino, C3-7cycloalkyl, hydroxy, C1-7alkoxy, haloC1-7alkyl, —NRaRb, C6-10aryl, heteroaryl or heterocyclyl;
• wherein Ra and Rb for each occurrence are independently H or C1-7alkyl;
• R3 is A1-C(O)X1;
• R5 is H, halo, hydroxy, C1-7alkoxy, halo, C1-7alkyl or halo-C1-7alkyl;
• and
• X and X1 are independently OH, —O—C1-7alkyl, —NRaRb, —NHS(O)2—C1-7alkyl, —NHS(O)2-benzyl or —O—C6-10aryl;
• wherein alkyl is optionally substituted with one or more substituents independently selected from the group consisting of C6-10aryl, heteroaryl, heterocyclyl, C(O)NH2, C(O)NH—C1-6alkyl, and C(O)N(C1-6alkyl)2;
• B1 is —C(O)NH— or —NHC(O)—;
• A1 is a linear or branched C1-7alkylene;
• which is optionally substituted with one or more substituents independently selected from the group consisting of halo, C3-7cycloalkyl, C1-7alkoxy, hydroxy and O-acetate;
• in which two geminal alkyl can optionally combine to form a C3-7cycloalkyl;
• or
• n is 0, 1, 2, 3, 4 or 5;
• wherein each heteroaryl is a monocyclic or bicyclic aromatic ring comprising 5-10 ring atoms selected from carbon atoms and 1 to 5 heteroatoms, and
• each heterocyclyl is a monocyclic saturated or partially saturated but non-aromatic moiety comprising 4-7 ring atoms selected from carbon atoms and 1-5 heteroatoms, wherein each heteroatom of a heteroaryl or a heterocyclyl is independently selected from O, N and S.