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US 2013/0096124 A1Published application
5-aryl isoxazolines for controlling pests
AssigneeNovartis AG
InventorsSteve Nanchen, Noelle Gauvry, Thomas Goebel
Life of this patent
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Abstract
The present invention relates to new isoxazoline compounds of formula wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful in the control of parasites, in particular ectoparasites, in and on vertebrates.
Claims16
A compound of formula
- including all geometric and stereoisomers, N-oxides, S-oxides and salts thereof, wherein
- X, is S(O)m, O or NR5′ and X1 and X2 are each independently of the other CR3′ or N,
- n is an integer from 0 to 4;
- m is an integer from 0 to 2;
- R5′ is H, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkylcarbonyl or C1-C6-alkoxycarbonyl;
- B1, B2 and B3 are each independently selected from the group consisting of CR2′ and N;
- each R2′ is independently of the other H or R2;
- each R3′ is independently of the other H or R3;
- R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C4-C7-alkylcycloalkyl or C4-C7-cycloalkylalkyl, each unsubstituted or substituted with one or more substituents independently selected from R4;
- R4 is halogen, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkyl-sulfonyl, cyano or nitro;
- each R2 is independently halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, N-mono- or N,N-di-C1-C6-alkylamino, C1-C6-alkoxycarbonyl, cyano (—CN) or nitro (—NO2);
- each R3 is independently H, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkyl-sulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, amino,
- N-mono- or N,N-di-C1-C6-alkylamino, C1-C6-alkoxycarbonyl, cyano, nitro or unsubstituted or halogen-, C1-C6-alkyl-, C1-C6-haloalkyl-, C1-C6-alkoxy-, C1-C6-haloalkoxy-, amino-, cyano- or
- nitro-substituted phenyl, pyridyl or pyrimidyl;
- R5 is H, C1-C6-alkyl, C1-C6-haloalkyl, halogen or cyano;
- or R5 and X2 together with the intermediate C-atoms form a 5- or 6-membered carbocyclic ring;
- R6 is H;
- C1-C6-alkyl, which is unsubstituted or substituted by C1-C4-alkoxy, cyano, phenyl, ethenyl or ethynyl;
- C2-C7-alkylcarbonyl;
- C2-C7-haloalkylcarbonyl;
- C2-C7-alkoxycarbonyl;
- Z is C1-C6-alkyl, a group —C(O)-Q, a group —C(S)-Q or a group —S(O)t-Q;
- t is 1 or 2;
- Q is C1-C6-alkoxy;
- C1-C6-haloalkoxy;
- C1-C6-alkylthio;
- C1-C6-haloalkylthio;
- NR7R8;
- CO2R7;
- COR7;
- C1-C6-alkyl which is unsubstituted or substituted by C3-C6-cycloalkyl, halogen, cyano, nitro, hydroxy, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, NHCOR7, C1-C6-alkoxycarbonyl, sulfonamido, N-mono- or N,N, di-C1-C4-alkylsulfonamido, CONR7R8, C2-C6-alkanoyl, unsubstituted or C1-C2-alkyl-, C1-C2-haloalkyl-, C1-C2-alkoxy-, C1-C2-haloalkoxy-, halogen-, cyano- or C1-C4-alkoxycarbonyl-substituted C6-C10-aryl, or unsubstituted or C1-C2-alkyl-, C1-C2-haloalkyl-, C1-C2-alkoxy-, C1-C2-haloalkoxy-, halogen-, cyano- or C1-C4-alkoxycarbonyl-substituted 4- to 6-membered heterocyclyl;
- C2-C6-alkenyl;
- C2-C6-alkynyl;
- C3-C6-cycloalkyl which is unsubstituted or substituted by halogen, C1-C2-alkyl or C1-C2-haloalkyl;
- C6-C10-aryl unsubstituted or substituted by C1-C2-alkyl, C1-C2-haloalkyl, C1-C2-alkoxy, C1-C2-haloalkoxy, halogen, cyano or C1-C4-alkoxycarbonyl;
- or 4- to 6-membered heterocyclyl unsubstituted or substituted by C1-C2-alkyl, C1-C2-haloalkyl, C1-C2-alkoxy, C1-C2-haloalkoxy, halogen, cyano or C1-C4-alkoxycarbonyl;
- and
- R7 and R8 are each independently of the other H, C1-C6-alkyl, C1-C6-haloalkyl or C3-C6-cycloalkyl, alkylcycloalkyl, C2-C6-alkenyl or C2-C6-alkynyl.
35 more elements
16-18. (canceled)
Dependencies are inferred from the claim text.