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US 2013/0096107 A1Published application
Use of aminodihydrothiazines for the treatment or prevention of diabetes
AssigneeHoffmann-La Roche Inc.
InventorsJeremy Beauchamp, Agnes Benardeau, Hans Hilpert, Cristiano Migliorini, William Riboulet, Haiyan Wang
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Abstract
This invention relates to compounds of formula I, wherein R1 to R3 are as defined herein, as well as pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and methods for using such compounds for the treatment or prevention of diabetes, particularly type 2 diabetes.
Claims11
A compound of formula Ia,
- wherein
- R1 is ethyl;
- R2 is selected from the group consisting of C1-7-alkyl, halogen, cyano and C1-7-alkoxy;
- and
- R3 is aryl or heteroaryl, said aryl or heteroaryl being unsubstituted or substituted by one, two or three groups selected from the group consisting of C1-7-alkyl, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy, cyano, hydroxy-C1-7-alkyl, oxo and phenyl;
- or a pharmaceutically acceptable salt thereof.
3 more elements
A method for the treatment or prevention of diabetes, which method comprises administering, to a human being or animal in need thereof, a therapeutically active amount of a compound of formula I,
- wherein
- R1 is C1-7-alkyl or C3-7-cycloalkyl;
- R2 is selected from the group consisting of hydrogen, C1-7-alkyl, halogen, cyano and C1-7-alkoxy;
- and
- R3 is aryl or heteroaryl, said aryl or heteroaryl being unsubstituted or substituted by one, two or three groups selected from the group consisting of C1-7-alkyl, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy, cyano, hydroxy-C1-7-alkyl, oxo and phenyl;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.