Pharmaceutical multimeric particles, and manufacturing method for same

Pharmaceutical multimeric particles, wherein a pharmaceutical multimer is characterized by being formed by intermolecular dehydration condensation between a of plural drugs represented by general formula (1), and being hydrolyzed in vivo to plural drugs represented by the above-mentioned general formula (1), and said pharmaceutical multimeric particles are characterized by being obtained by pouring a solution of the pharmaceutical multimer dissolved in a water-miscible organic solvent into water.

• [Chemical Formula (1)]
• Aa)k (1)
• wherein, in the general formula (1), A is a k-valent organic group, k is an integer of 2 or more, and a is a monovalent substituent. k of a may be the same or different each other.

Pharmaceutical multimeric particles of a drug represented by general formula (2), that are characterized by being obtained by pouring a solution of the compound represented by the following general formula (3) dissolved in a water-miscible organic solvent into water.

• wherein, in the general formula (2) and general formula (3), A is a divalent organic group, a and b are each a substituent selected from hydroxyl group, amino group, carboxyl group, thiol group and hydrogen atom (provided that limited to the hydrogen atom on secondary amine). In the general formula (3), n is an integer of 1 or more, and d is a divalent substituent wherein by in vivo hydrolysis of d, the compound represented by the general formula (3) is converted to n+1 of drugs represented by the general formula (2).

A pharmaceutical dimer having the following structural formula.

A manufacturing method of pharmaceutical multimeric particles, which is characterized by pouring a solution of pharmaceutical multimer dissolved in a water-miscible organic solvent into water, and said pharmaceutical multimer is characterized by being formed by intermolecular condensation between a of plural drugs represented by the general formula (1), and being converted in the living body to plural drugs represented by the general formula (1).

• [Chemical Formula (1)]
• Aa)k (1)
• wherein, in the general formula (1), A is a k-valent organic group, k is an integer of 2 or more, and a is a monovalent substituent. k of a may be the same or different each other.

A manufacturing method of pharmaceutical multimeric particles, which is characterized by pouring a solution of pharmaceutical multimer having a structure represented by the general formula (5) dissolved in a water-miscible organic solvent into water.