Compositions and methods of treatment for inflammatory diseases
AssigneeThe Board of Regents of the University of Oklahoma
InventorRichard F. HARTY
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Abstract
Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.
Claims19
An oral pharmaceutical composition comprising:
- a therapeutically effective amount of 5-aminosalicylic acid or a pharmaceutically-acceptable salt thereof, and a therapeutically effective amount of N-acetylcysteine or a pharmaceutically-acceptable salt thereof, together disposed in a pharmaceutically-acceptable carrier, wherein the pharmaceutical composition is formulated for oral administration to a subject.
A method of treating an inflammatory bowel disease in a subject, the method comprising orally administering to the subject a therapeutically-effective amount of 5-aminosalicylic acid or a pharmaceutically-acceptable salt thereof, and a therapeutically-effective amount of N-acetylcysteine or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.