Transition metal complexes of amino acids and related ligands and their use as catalysts, anti-microbials, and anti-cancer agents

A piano stool complex of Formula 3:

• wherein M is chosen from any transition, lanthanide, or actinide metal;
• and
• wherein L1, L2 is a chelating amino acid and where L3 is a halogen;
• and
• wherein
• is an aromatic ligand capable of pi-complexing to the metal;
• or an enantiomer thereof, or a diastereoisomer thereof, or a racemic mixture of stereoisomers thereof, or a salt thereof, or any combination thereof.

A square planar metal complex of Formula 4:

• wherein R1-R8 are the same or different and are chosen from H, CH3, CH2CH3, C6H5 and any C1-20 alkyl substituent;
• wherein
• is an unsubstituted C1-20 alkene group, or an alkene group substituted with a chelating dialkene or substituted with a substituted or unsubstituted olefin or cyclic olefin;
• and
• wherein M is any transition or lanthanide or actinide metal;
• or an enantiomer thereof, or a diastereoisomer thereof, or a racemic mixture of stereoisomers thereof, or a salt thereof, or any combination thereof.

A method of using an octahedral amino acid complex of Formula 2:

• wherein M is chosen from cobalt, rhodium, iridium, iron, ruthenium, osmium, manganese, technetium, and rhenium, or any transition or lanthanide or actinide metal;
• and
• wherein R1-2 are the same or different and are chosen from H, CH3, CH2CH3, C6H5, and C1-20 alkyl groups, and optionally R1 and/or R2 either together or separately form a 3-, 4-, 5-, 6-, 7-, or 8-membered ring with the carbon to which they are attached and with nitrogen to which the carbon is attached;
• or an enantiomer thereof, or a diastereoisomer thereof, or a racemic mixture of stereoisomers thereof, or a salt thereof, or any combination thereof;
• as an anti-microbial, anti-bacterial, or anti-cancer agent.