Infant nutrition for improving fatty acid composition of brain membranes
AssigneeN.V. Nutricia
InventorsEline Marleen Van Der Beek, Marieke Abrahamse-Berkeveld, Annemiek Lidewij Schipper, Gelske Speelmans
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Abstract
The present invention relates to infant nutrition, in particular to infant nutrition comprising special lipid globules for improvement of the fatty acid composition in brain membranes.
Claims21
1-16. (canceled)
A method for altering brain membrane fatty acid composition selected from the group consisting of i) increasing brain membrane fluidity, ii) increasing brain membrane PUFA, iii) increasing brain membrane LC-PUFA, iv) decreasing brain membrane ratio of n6/n3 LC-PUFA, v) decreasing brain membrane ratio of n6/n3 PUFA, vi) increasing brain membrane n3 PUFA, vii) increasing brain membrane n3 LC-PUFA and viii) increasing brain membrane DHA, in a human subject, the method comprising administering to the human subject a nutritional composition comprising:
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids wherein said lipid globules have:
- (i) a volume-weighted mode diameter above 1.0 μm, and/or
- (ii) a diameter of 2 to 12 μm in an amount of at least 45 volume % based on total lipid.
A method for amelioration of cognitive performance in a human subject above 36 months of age, the method comprising administering to said human subject at an age between 0 and 36 months a nutritional composition comprising:
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids, wherein said lipid globules have:
- (i) a volume-weighted mode diameter above 1.0 μm, and/or
- (ii) a diameter of 2 to 12 μm in an amount of at least 45 volume % based on total lipid.
A method for the prevention and/or treatment of a disorder associated with decreased brain membrane fluidity and/or associated with decreased brain membrane PUFA content and/or LC-PUFA content and/or increased ratio of n6/n3 LC-PUFA, and/or increased ratio of n6/n3 PUFA, the method comprising administering to a human subject in need thereof a nutritional composition comprising:
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids wherein said lipid globules have:
- (i) a volume-weighted mode diameter above 1.0 μm, and/or
- (ii) a diameter of 2 to 12 μm in an amount of at least 45 volume % based on total lipid.
A nutritional composition comprising:
- 10 to 50 wt. % vegetable lipids based on dry weight of the composition, and lipid globules with a core comprising said vegetable lipids wherein said lipid globules have:
- (i) a volume-weighted mode diameter above 1.0 μm, and/or
- (ii) a diameter of 2 to 12 μm in an amount of at least 45 volume % based on total lipid.
Dependencies are inferred from the claim text.