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US 2013/0096081 A1Published application
Dermal filler compositions
AssigneeAllergan, Inc.
InventorsGabriel N. Njikang, Xiaojie Yu, Futian Liu, Nicholas J. Manesis
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Abstract
The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.
Claims29
A method of making an injectable dermal filler composition for treating wrinkles in skin, the method comprising the steps of crosslinking hyaluronic acid (HA) with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.
A dermal filler composition for treatment of superficial wrinkles in skin, the composition comprising:
- a hyaluronic acid component crosslinked with a di-amine or multiamine crosslinker;
- and
- a carbodiimide coupling agent;
- the composition being substantially optically transparent;
- and
- the composition exhibiting reduced or no perceptible blue discoloration when administered into a dermal region of a patient.
3 more elements
Dependencies are inferred from the claim text.