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US 2013/0096055 A1Published application
Long-acting y2 receptor agonists
AssigneeNovo Nordisk A/S
InventorsJacob Kofoed, Lars Ynddal, Soeren Oestergaard, Rasmus Joergensen, Flemming Sejer Nielsen, Cecilia Nilsson, Jens Kaalby Thomsen
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Abstract
The present invention relates to PYY derivatives comprising a serum albumin binding side chain, wherein said derivative has a half-life of at least 7 hours as determined by Assay (IV) described herein as well as compositions comprising said derivative and its use in therapy.
Claims16
A PYY derivative comprising a serum albumin binding side chain, wherein
- said derivative has a half-life of at least 7 hours as determined by Assay (IV), and wherein
- said serum albumin binding side chain comprises an alkyl chain of at least 14 carbon atoms, and wherein
- said alkyl chain comprises a distal carboxylic acid group or a distal tetrazole group, and wherein
- said serum albumin binding side chain is attached to the N-terminal amino group or an amino acid in a position selected from the group consisting of position 1, 3, 6, 7, 9, 10, 11, 12, 14, 15, 17, 18, 19, 21, 22, 23 and 30, wherein said position is relative to hPYY(1-36).
1 more element
(canceled)
Dependencies are inferred from the claim text.