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AssigneeThe UAB Research Foundation
InventorsOlaf Kutsch, Michael Niederweis, Frank Wolschendorf, Alexandra Duverger, Frederic Wagner
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Provided herein are methods or reactivating a latent Human Immunodeficiency Virus (HIV) infection in a cell. The methods comprise modulating a level of NF-κB activity in the cell by contacting the cell with an agent that produces a transient first increase in the level of NF-κB activity without a second delayed increase in NF-κB activity. Optionally, a second agent is used to prime the reactivation. Also provided herein is an isolated Massilia bacterium or population thereof capable of producing a HIV-1 reactivating factor (HRF). Also provided are methods of culturing the Massilia bacteria. Further provided are methods of reactivating a latent Human Immunodeficiency Virus-1 (HIV-1) infection in a subject comprising administering to the subject a HIV-1 reactivating factor produced by Massilia bacteria, optionally with a priming agent.
A method of reactivating a latent Human Immunodeficiency Virus (HIV) infection in a cell comprising modulating a level of NF-κB activity in the cell by contacting the cell with a first agent that produces a transient first increase in the level of NF-κB activity without a second delayed increase in NF-κB activity.
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An isolated Massilia bacterium or population thereof for producing a Human Immunodeficiency Virus (HIV) reactivating factor (HRF).
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A composition comprising a purified population of a Massilia timonae strain having ATCC Accession number PTA-10969.
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An isolated Human Immunodeficiency Virus (HIV) reactivating factor (HRF) produced by the Massilia timonae strain having ATCC accession number BAA-703.
A method of reactivating a latent Human Immunodeficiency Virus (HIV) infection in a subject comprising administering to a subject a HIV reactivating factor (HRF) produced by Massilia bacteria or a reactivating fragment of the HRF produced by Massilia bacteria.
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A method of treating an HIV infection in a subject, the method comprising:
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A method of producing an HIV reactivating factor comprising (a) culturing a Massilia bacteria in a mammalian cell culture medium under conditions that allow for the secretion of the HRF into the culture media;
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Dependencies are inferred from the claim text.