Lectins and uses thereof
AssigneeThe Regents of the University of Michigan
InventorsDavid Markovitz, Michael Swanson, Irwin Goldstein, Harry Winter
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Abstract
The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and re-search use. In particular, the present invention provides antiviral and antimicrobial lectin compounds (BanLec) isolated from bananas. These compounds have low mitogenicity and pro-inflammatory activity whilst maintaining anti-HIV-1 activity.
Claims19
A composition comprising a variant BanLec polypeptide, wherein said variant BanLec polypeptide exhibits antiviral or antimicrobial activity, and wherein said BanLec polypeptide exhibts reduced mitogenic activity relative to a wild type BanLec polypeptide.
Dependencies are inferred from the claim text.