Highly active polypeptides and methods of making and using the same
AssigneeLongevity Biotech, Inc.
InventorScott J Shandler
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Abstract
This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an a-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. The compositions and methods of this invention are particularly useful to identify novel therapeutic modulators of in-vivo receptor activity with extended half-lives and relevant bioactivity as compared to the naturally translated polypeptides upon which the analogs are derived.
Claims21
1-52. (canceled)
A composition comprising a vasoactive intestinal peptide (VIP) analog, wherein the analog comprises an α-amino acid and at least one β-amino acid.
A method of identifying a modulator of human VIP receptor activity comprising:
- a) contacting a human VIP receptor with a VIP analog, wherein the analog comprises an α-amino acid and at least one β-amino acid;
- b) measuring the association of the VIP analog to the human VIP receptor in the presence and absence of an unknown compound;
- and
- c) comparing the rate of association of the VIP analog to the human VIP receptor in the presence of the unknown compound to the rate of association of the VIP analog to the human VIP receptor in the absence of the unknown compound.
The kit of 62, wherein a first container comprises the composition and a second container comprises a vehicle for administration of the composition.
A composition comprising an analog derived from any one of the polypeptides disclosed in Tables 1, 2, 3, or 4, wherein the analog comprises an α-amino acid and at least one β-amino acid.
A composition comprising a secretin family analog or an insulin family analog, wherein said analog comprises an α-amino acid and at least one β-amino acid.
Dependencies are inferred from the claim text.